Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010

Liaqat Ali Chaudhry; Nagamani Rambhala; Ali Saad Al-Shammri; Jaffar A. Al-Tawfiq

doi:10.1016/j.jegh.2011.10.001

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Volume 2, Issue 1, March 2012, Pages 57 - 60

Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010

Authors

Liaqat Ali Chaudhry^a^{, *}^,dr_liaqatali@hotmail.com, Nagamani Rambhala^b, Ali Saad Al-Shammri^c, Jaffar A. Al-Tawfiq^d

^aDepartment of Medicine & Chest, Diseases, Dammam Medical Complex (MOH), Saudi Arabia

^bMicrobiology Lab., Dammam Medical Complex (MOH), Saudi Arabia

^cBlood Bank & Regional Lab., Dammam Medical Complex (MOH), Saudi Arabia

^dSpeciality Internal Medicine, Saudi ARAMCO Medical Services Organization, Dhahran, Saudi Arabia

^*Corresponding author. Address: Chief of Tuberculosis Centre, Department of Medicine & Chest, Diseases, Dammam Medical Complex (MOH), P.O. Box 132, Dammam 31411, Saudi Arabia. Tel.: +966 509949470.

Corresponding Author

Liaqat Ali Chaudhrydr_liaqatali@hotmail.com

Received 5 May 2011, Revised 15 October 2011, Accepted 20 October 2011, Available Online 24 December 2011.

DOI: 10.1016/j.jegh.2011.10.001 How to use a DOI?
Keywords: Incidence; Prevalence; Resistance; Eastern Saudi Arabia; Tuberculosis
Abstract: Objective: To examine the patterns of antituberculous drug resistance of Mycobacterium tuberculosis in patients with pulmonary and extra-pulmonary tuberculosis in the Eastern province of the Kingdom of Saudi Arabia.

Methods: This is a retrospective study of antibiotic susceptibility of 1681 non-repetitive M. tuberculosis isolates from 1/2003 to 6/2010.

Results: Of the total patients, 41% (n = 687) were Saudis and 59% (n = 994) were non-Saudis. The pulmonary and extra-pulmonary specimens constituted 68% (n = 1148) and 32% (n = 533), respectively. The incidence of resistance was 15.5% to one or more of anti-tuberculosis drugs. The resistance rates to first-line drugs were as follows: streptomycin (10.4%), INH (9.8%), rifampicin (1.5%) and ethambutol (1.0%). Multi-drug resistant tuberculosis was present in 1.4% (n = 24) of the sample.

Conclusion: INH resistance in this study was relatively high, whereas the rate of MDR-TB was low. A rate of MDR-TB observed in this study was 1.4%. Thus, an empiric four-drug therapy is required to treat patients with tuberculosis in this area of Saudi Arabia.
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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<Previous Article In Issue

Journal: Journal of Epidemiology and Global Health
Volume-Issue: 2 - 1
Pages: 57 - 60
Publication Date: 2011/12/24
ISSN (Online): 2210-6014
ISSN (Print): 2210-6006
DOI: 10.1016/j.jegh.2011.10.001 How to use a DOI?
Open Access: This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)

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ris enw bib

TY  - JOUR
AU  - Liaqat Ali Chaudhry
AU  - Nagamani Rambhala
AU  - Ali Saad Al-Shammri
AU  - Jaffar A. Al-Tawfiq
PY  - 2011
DA  - 2011/12/24
TI  - Patterns of antituberculous drug resistance in Eastern Saudi Arabia: A 7-year surveillance study from 1/2003 to 6/2010
JO  - Journal of Epidemiology and Global Health
SP  - 57
EP  - 60
VL  - 2
IS  - 1
SN  - 2210-6014
UR  - https://doi.org/10.1016/j.jegh.2011.10.001
DO  - 10.1016/j.jegh.2011.10.001
ID  - AliChaudhry2011
ER  -

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