Materials Highlights

Volume 2, Issue 3, June 2021, Pages 68 - 70

Nebulizer, Inhaled Remdesivir Nanoparticle Co-administered with Withania Somnifera may Minimize the Hepatotoxicity in COVID-19

Authors
R. Velmurugan1, P. Manoj Kumar2, Keerthi G.S. Nair2, *
1Department of Pharmacology, School of Pharmaceutical Sciences, Vels Institute of Science Technology and Advanced Studies, Chennai 600117, India
2Department of Pharmaceutics, The Dale View College of Pharmacy and Research Centre, Punalal, Poovachal, Trivandrum, Kerala 695575, India
*Corresponding author. Email: keerthinair.dr@gmail.com
Corresponding Author
Keerthi G.S. Nair
Received 17 March 2021, Accepted 5 July 2021, Available Online 16 July 2021.
DOI
https://doi.org/10.2991/mathi.k.210708.001How to use a DOI?
Keywords
COVID-19, remdesivir, hepatotoxicity, nanoparticle, target delivery, ashwagandha, improved clinical outcome
Abstract

Remdesivir is a broad spectrum antiviral agent meant to inhibit viral RNA polymerases against members of several virus families, including filoviruses. Although reported for significant clinical improvements in COVID-19, a detailed observation of the connection with the drawbacks of remdesivir therapy was poor pulmonary distribution and hepatotoxicity (transaminase elevation) was recorded that resulted in discontinuation of remdesivir therapy. Nanodrug delivery facilitates a large drug payload to the targeted site improving the efficacy. With the lesser dose administered, could be expected for minimized adverse events. Additional payload of ashwagandha will protect the liver from the damages caused if any. Remdesivir in nanoformulation may be a safe and an effective therapeutic agent for COVID 19 when co-adminstered with ashwagandha.

Copyright
© 2021 The Authors. Published by Atlantis Press B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

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Journal
Materials Highlights
Volume-Issue
2 - 3
Pages
68 - 70
Publication Date
2021/07
ISSN (Online)
2666-4933
DOI
https://doi.org/10.2991/mathi.k.210708.001How to use a DOI?
Copyright
© 2021 The Authors. Published by Atlantis Press B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - JOUR
AU  - R. Velmurugan
AU  - P. Manoj Kumar
AU  - Keerthi G.S. Nair
PY  - 2021
DA  - 2021/07
TI  - Nebulizer, Inhaled Remdesivir Nanoparticle Co-administered with Withania Somnifera may Minimize the Hepatotoxicity in COVID-19
JO  - Materials Highlights
SP  - 68
EP  - 70
VL  - 2
IS  - 3
SN  - 2666-4933
UR  - https://doi.org/10.2991/mathi.k.210708.001
DO  - https://doi.org/10.2991/mathi.k.210708.001
ID  - Velmurugan2021
ER  -