The Effect of Tamarind Leaves (tamarindus indica linn) and Acarbose on Body Weight in Rats Type 2 Diabetes Mellitus Model

DOI

10.2991/ahsr.k.210127.010How to use a DOI?

Keywords

Tamarind Leaves, STZ, NA, Body Weight

Abstract

Diabetes mellitus is a disease that causes an increase in blood glucose so that glucose in the calories is difficult to enter the cell and glycogenolysis process occurs then continues to the process of gluconeogenesis so that the body lacks energy and unloads food reserves in the muscles and adipose which results in the occurrence of weight loss in people with T2DM. Antioxidants are needed, namely tamarind leaves to help glucose enter cells. This study used 30 wistar rats that were 8 weeks old and weighed 150-200 g. Rats were induced with STZ as much as 45 mg / kg, then Na as much as 110 mg / kg. In this study, rats were grouped into 5 groups namely, KN groups which were DMT2 rats without treatment, KP group who were DMT2 rats given acarbose drugs by 1.8 mg / KgBB / day and Group P1, P3, P3 were given leaf treatment tamarind with a dose of 28.56, and 112 mg / 200gr / day for 14 days. All data were collected and analyzed using ANOVA and LSD post hoc with p value <0.05. In fasting blood glucose, the mean of all groups of rats was 264.83 ± 1.47 and the mean of body weight of rats after STZ induction was 180 ± 3.84. After 7 days of treatment, the body weight of rats in the treatment of KP (184.17 ± 3.18), P1 (182.50 ± 6.15), P2 (182.17 ± 5.77), and P3 (189.67) ± 2.65) increased significantly, whereas in the KN group (173.67 ± 4.59) weight loss occurred in the DMT2 model rats. Giving extract of tamarind leaves in P3 is better than KP which is an acarbose drug. Provision of tamarind leaves for 7 days, in the treatment group P3 increased body weight of rats and treatments P1 and P2 increased body weight the same as the treatment group KP (acarbose).

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Download article (PDF)

TY  - CONF
AU  - Devi Novia
AU  - Sugiarto
AU  - Yulia Lanti Retno Dewi
PY  - 2021
DA  - 2021/01/27
TI  - The Effect of Tamarind Leaves (tamarindus indica linn) and Acarbose on Body Weight in Rats Type 2 Diabetes Mellitus Model
BT  - Proceedings of the International Conference on Health and Medical Sciences (AHMS 2020)
PB  - Atlantis Press
SP  - 43
EP  - 45
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210127.010
DO  - 10.2991/ahsr.k.210127.010
ID  - Novia2021
ER  -