Study of Heparanase Inhibitors (Genus: Felis) Among Bioactive Compounds Produced by Plants in Volgograd Regions
- 10.2991/aer.k.200202.046How to use a DOI?
- inhibitors, heparanase, HPSE, docking, screening, PhytoChem, Autodock Vina
The paper describes a search and selection of potential heparanase inhibitors. This enzyme is inhibited to protect an organism against various diseases such as chronic kidney disease and diabetic nephropathy. These diseases are widely distributed and often lead to death. Searching low-cost plant analogs of compounds which are able to inhibit their target protein activity can make the treatment cheaper and more efficient. The study has been carried out by means of Autodock Vina software to perform molecular docking and Protein Data Bank to obtain a crystal structure. Molecular docking has computed Folate, Folate, Riboflavin to be the most potential heparanase ligands. These compounds are produced by widely distributed plants and known to be harmless to different species.
- © 2020, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Margarita Postnova AU - Yulia Zimina AU - Galina Sroslova AU - Alexey Bolkunov AU - Alexander Kovalenko PY - 2020 DA - 2020/02/08 TI - Study of Heparanase Inhibitors (Genus: Felis) Among Bioactive Compounds Produced by Plants in Volgograd Regions BT - Proceedings of the IV International Scientific and Practical Conference 'Anthropogenic Transformation of Geospace: Nature, Economy, Society' (ATG 2019) PB - Atlantis Press SP - 230 EP - 233 SN - 2352-5401 UR - https://doi.org/10.2991/aer.k.200202.046 DO - 10.2991/aer.k.200202.046 ID - Postnova2020 ER -