Proceedings of the IV International Scientific and Practical Conference 'Anthropogenic Transformation of Geospace: Nature, Economy, Society' (ATG 2019)

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Study of Heparanase Inhibitors (Genus: Felis) Among Bioactive Compounds Produced by Plants in Volgograd Regions

Authors
Margarita Postnova, Yulia Zimina, Galina Sroslova, Alexey Bolkunov, Alexander Kovalenko
Corresponding Author
Margarita Postnova
Available Online 8 February 2020.
DOI
10.2991/aer.k.200202.046How to use a DOI?
Keywords
inhibitors, heparanase, HPSE, docking, screening, PhytoChem, Autodock Vina
Abstract

The paper describes a search and selection of potential heparanase inhibitors. This enzyme is inhibited to protect an organism against various diseases such as chronic kidney disease and diabetic nephropathy. These diseases are widely distributed and often lead to death. Searching low-cost plant analogs of compounds which are able to inhibit their target protein activity can make the treatment cheaper and more efficient. The study has been carried out by means of Autodock Vina software to perform molecular docking and Protein Data Bank to obtain a crystal structure. Molecular docking has computed Folate, Folate, Riboflavin to be the most potential heparanase ligands. These compounds are produced by widely distributed plants and known to be harmless to different species.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the IV International Scientific and Practical Conference 'Anthropogenic Transformation of Geospace: Nature, Economy, Society' (ATG 2019)
Series
Advances in Engineering Research
Publication Date
8 February 2020
ISBN
10.2991/aer.k.200202.046
ISSN
2352-5401
DOI
10.2991/aer.k.200202.046How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Margarita Postnova
AU  - Yulia Zimina
AU  - Galina Sroslova
AU  - Alexey Bolkunov
AU  - Alexander Kovalenko
PY  - 2020
DA  - 2020/02/08
TI  - Study of Heparanase Inhibitors (Genus: Felis) Among Bioactive Compounds Produced by Plants in Volgograd Regions
BT  - Proceedings of the IV International Scientific and Practical Conference 'Anthropogenic Transformation of Geospace: Nature, Economy, Society' (ATG 2019)
PB  - Atlantis Press
SP  - 230
EP  - 233
SN  - 2352-5401
UR  - https://doi.org/10.2991/aer.k.200202.046
DO  - 10.2991/aer.k.200202.046
ID  - Postnova2020
ER  -