Acute Toxicity of Seleniferous Pleurotus Geesteranus Mycelia and Antioxidation against D-galactose-induced Mice

DOI

https://doi.org/10.2991/bbe-16.2016.18How to use a DOI?

Keywords

Seleniferous mushroom, Pleurotus geesteranus singer, Antioxidant, Acute toxicity, Mouse.

Abstract

Liquid culture of seleniferous mycelia of Pleurotus geesteranus Singer (SeMyc-P) was evaluated for its acute toxicity in supplement application and antioxidant against D-galactose induced oxidation damaged mice. Maximum Tolerant Dose (MTD) of SeMyc-P was about 20g/kg bw for mice to define safety application for selenium supplement against acute toxicity. Comparing with carboxymethyl cellulose sodium (CMC) control and VitE standard group, SeMyc-P in 10-days administration increased blood GSH-Px about 24.8-52.0% and 17.1-42.6%, respectivily. By 45-days administration against D-galactose induced oxidative stress mice, the optimal given level of SeMyc-P was 0.2µg/hd/d equivalent to 5-times of DRIs in selenium for Recommended Nutritional Intake (RNI=50 g/d), which increased blood GSH-Px 18.48% than CK-m group concomitant with decreasing MDA and protein carbonyl for 22.19% and 44.16%, respectively.

Open Access

This is an open access article distributed under the CC BY-NC license.

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TY  - CONF
AU  - Junchen Chen
AU  - Li Wu
AU  - Hengsheng Shen
AU  - Minjie Weng
AU  - Pufu Lai
PY  - 2016/07
DA  - 2016/07
TI  - Acute Toxicity of Seleniferous Pleurotus Geesteranus Mycelia and Antioxidation against D-galactose-induced Mice
BT  - International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 102
EP  - 111
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.18
DO  - https://doi.org/10.2991/bbe-16.2016.18
ID  - Chen2016/07
ER  -