Acute Toxicity of Seleniferous Pleurotus Geesteranus Mycelia and Antioxidation against D-galactose-induced Mice
- Junchen Chen, Li Wu, Hengsheng Shen, Minjie Weng, Pufu Lai
- Corresponding Author
- Junchen Chen
Available Online July 2016.
- https://doi.org/10.2991/bbe-16.2016.18How to use a DOI?
- Seleniferous mushroom, Pleurotus geesteranus singer, Antioxidant, Acute toxicity, Mouse.
- Liquid culture of seleniferous mycelia of Pleurotus geesteranus Singer (SeMyc-P) was evaluated for its acute toxicity in supplement application and antioxidant against D-galactose induced oxidation damaged mice. Maximum Tolerant Dose (MTD) of SeMyc-P was about 20g/kg bw for mice to define safety application for selenium supplement against acute toxicity. Comparing with carboxymethyl cellulose sodium (CMC) control and VitE standard group, SeMyc-P in 10-days administration increased blood GSH-Px about 24.8-52.0% and 17.1-42.6%, respectivily. By 45-days administration against D-galactose induced oxidative stress mice, the optimal given level of SeMyc-P was 0.2µg/hd/d equivalent to 5-times of DRIs in selenium for Recommended Nutritional Intake (RNI=50 g/d), which increased blood GSH-Px 18.48% than CK-m group concomitant with decreasing MDA and protein carbonyl for 22.19% and 44.16%, respectively.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Junchen Chen AU - Li Wu AU - Hengsheng Shen AU - Minjie Weng AU - Pufu Lai PY - 2016/07 DA - 2016/07 TI - Acute Toxicity of Seleniferous Pleurotus Geesteranus Mycelia and Antioxidation against D-galactose-induced Mice BT - International Conference on Biomedical and Biological Engineering PB - Atlantis Press SN - 2468-5747 UR - https://doi.org/10.2991/bbe-16.2016.18 DO - https://doi.org/10.2991/bbe-16.2016.18 ID - Chen2016/07 ER -