Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

Temporal Expression MicroRNA-21 in Serum of Patients with Spinal Cord Injury

Authors
Hongyan Li, Dongxu Zhao, Minglei Zhang
Corresponding Author
Hongyan Li
Available Online July 2016.
DOI
https://doi.org/10.2991/bbe-16.2016.20How to use a DOI?
Keywords
Spinal cord injury, Serum, MicroRNA, MicroRNA-21
Abstract

Objective: To investigate the levels of microRNA-21 (miR-21) in the serum of patients with spinal cord injury (SCI) and to determine whether there was a correlation with degree of injury. Methods: Quantitative real-time reverse transcription–polymerase chain reaction( q-RT-PCR)was used to measure the serum levels ofmiR-21 at 1, 7 and 28 days and 3 months after SCI 42 in male and female SCI patients (n = 48) and compare with age and sex-matched patients with non spinal cord injuries (NSCI, n = 60) and healthy volunteers (n = 70). Correlations between serum miR-21 levels and age, sex and degree of injury were investigated. Results: The data from the present study show that the serum level of miR-21 immediately increased and peaked on day 7 post-SCI and then declined to the control level. There were no differences between NSCI group and normal control group at each time point. The expression level o fmiR-21 was related to the lesion degree of SCI. The age and sex of the patients did not influence miR-21 expression after SCI. Conclusions: These finding might provide reference for diagnosis and treatment and contribute to the identification of selective and temporal drug targeted therapy after SCI.

Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
Series
Advances in Biological Sciences Research
Publication Date
July 2016
ISBN
978-94-6252-216-9
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbe-16.2016.20How to use a DOI?
Copyright
© 2016, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Hongyan Li
AU  - Dongxu Zhao
AU  - Minglei Zhang
PY  - 2016/07
DA  - 2016/07
TI  - Temporal Expression MicroRNA-21 in Serum of Patients with Spinal Cord Injury
BT  - Proceedings of the 2016 International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SP  - 116
EP  - 122
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.20
DO  - https://doi.org/10.2991/bbe-16.2016.20
ID  - Li2016/07
ER  -