Proceedings of the 2016 International Conference on Biomedical and Biological Engineering

Anti-fatigue Effects of the Genistein Supplementation in Mice Subjected to Forced Swimming Test

Authors
Qiongli Hu
Corresponding Author
Qiongli Hu
Available Online July 2016.
DOI
https://doi.org/10.2991/bbe-16.2016.23How to use a DOI?
Keywords
Genistein, Anti-fatigue, Forced swimming test, Biochemical analysis, Mice.
Abstract
The present study was designed to evaluate the anti-fatigue effects of genistein in mice subjected to the forced swimming test. Mice were divided into four groups, i.e., one control group and three genistein treated groups. The treated groups were received doses of genistein (7, 15 and 30 mg/kg) dissolved in 1.0 mL of physiological saline, and the control group received same volume of physiological saline via oral gavage once a day. After 28 days, the mice were subjected to the forced swimming test, along with the determination of exhaustive swimming times and some biochemical parameters. The results showed that genistein could prolong exhaustive swimming time of mice, which was accompanied by decreases in blood lactic acid (BLA) and serum urea nitrogen (SUN) levels, increases in liver and muscle glycogen contents, and superoxide dismutase (SOD), glutathione peroxidase (GPx) and catalase (CAT) levels in serum. This indicated that genistein had anti-fatigue effects.
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Proceedings
International Conference on Biomedical and Biological Engineering
Part of series
Advances in Biological Sciences Research
Publication Date
July 2016
ISBN
978-94-6252-216-9
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbe-16.2016.23How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Qiongli Hu
PY  - 2016/07
DA  - 2016/07
TI  - Anti-fatigue Effects of the Genistein Supplementation in Mice Subjected to Forced Swimming Test
BT  - International Conference on Biomedical and Biological Engineering
PB  - Atlantis Press
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-16.2016.23
DO  - https://doi.org/10.2991/bbe-16.2016.23
ID  - Hu2016/07
ER  -