Proceedings of the 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)

Exercise Related Sudden Death: The Changes of Expression of Bax, Bcl-2 Protain in Myocardial Tissue and Brain Motor Cortex

Authors
Yu QIAN, Ren-Jun YANG, Jin YIN
Corresponding Author
Yu QIAN
Available Online May 2017.
DOI
https://doi.org/10.2991/bbe-17.2017.49How to use a DOI?
Keywords
Exercise related, Sudden, Death-Exercise-Fatigue-Bax -Bcl-2-LDH-2-BDNF.
Abstract
Purposes: Study the changes of cardiac and brain function of exercise related sudden death in rats under over fatigue state and explore the causes of sudden death preliminarily. Methods: Totally 72 male SD rats.7 rats were randomly selected as negative control group. The others were trained continuously with exhaustive loaded-swimming exercises to achieve the over fatigue state. Collect suffering-sudden death rats during and after exercise within 24 hours. Results: 1.Myocardial fibers were attenuated and some of fibers ruptured.2.Neuron is disordered in motor cortex slice, cells with a looser stroma.3.The level of serum LDH-2 sudden death group was slightly higher than negative control group.4.The expression level of Bax protein were increased in fatigue and sudden death group (P <0.05), while Bcl-2 protein decreased in heart tissue but increased in brain motor cortex (P<0.01). Conclusions: The changs of expression of Bax, Bcl-2 and BDNF maybe related to the protection-inhibition mechanism. Changes of Bax and Bcl-2 protein may be one of the causes of movement induced sudden death.
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Proceedings
2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
Part of series
Advances in Biological Sciences Research
Publication Date
May 2017
ISBN
978-94-6252-362-3
ISSN
2468-5747
DOI
https://doi.org/10.2991/bbe-17.2017.49How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Yu QIAN
AU  - Ren-Jun YANG
AU  - Jin YIN
PY  - 2017/05
DA  - 2017/05
TI  - Exercise Related Sudden Death: The Changes of Expression of Bax, Bcl-2 Protain in Myocardial Tissue and Brain Motor Cortex
BT  - 2nd International Conference on Biomedical and Biological Engineering 2017 (BBE 2017)
PB  - Atlantis Press
SN  - 2468-5747
UR  - https://doi.org/10.2991/bbe-17.2017.49
DO  - https://doi.org/10.2991/bbe-17.2017.49
ID  - QIAN2017/05
ER  -