Effect of Compound-Maqin-Decoction on P38MAPK and Foxp3 Protein Expression of Lung Issue in Asthmatic Rats

DOI

10.2991/bep-16.2017.18How to use a DOI?

Keywords

asthma; P38MAPK; Foxp3; Compound-Maqin-Decoction

Abstract

OBJECTIVE: To observe the effect of Compound-Maqin-Decoction (CMD) on p38MAPK and Foxp3protein expression of lung issue in asthmatic rats. METHODS: The asthmatic rat model was established by ovalbumin and was intervened with CMD. After inducing asthma and four-week treatment, the rats were sacrificed to immunohistochemicallly detect P38MAPK and Foxp3 protein expressions in lung tissue. RESULTS: After treatment, compared with model group, P38MAPK protein expression decreased and Foxp3 was increased in dexamethasone, large doses CMD and small doses CMD groups, there were statistically significant differences between dexamethasone group and large doses CMD group. Compared with dexamethasone group, P38MAPK protein expression decreased and Foxp3 was increased in large doses CMD and small doses CMD groups, there were statistically significant differences between dexamethasone group and large doses CMD group. Conclusion: CMD is effective in asthmatic airway remodeling, which may be due to its regulatory effect on the expressions of p38MAPK and Foxp3 protein.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Peng QIAN
AU  - Zhaoxia XU
AU  - Xueping LI
AU  - Sijing WANG
PY  - 2016/12
DA  - 2016/12
TI  - Effect of Compound-Maqin-Decoction on P38MAPK and Foxp3 Protein Expression of Lung Issue in Asthmatic Rats
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 84
EP  - 87
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.18
DO  - 10.2991/bep-16.2017.18
ID  - QIAN2016/12
ER  -