Crystallization of the Racemic Conglomerate and Racemic Compound of Efonidipine

DOI

10.2991/bep-16.2017.44How to use a DOI?

Keywords

efonidipine; crystallization; racemic conglomerate; racemic compound

Abstract

Efonidipine is a dual blocker of T-type and L-type calcium channels with 1, 4-dihydropyridine structure attached to a phosphonate skeleton. As a chiral compound, it has a special property that can exist as a racemic conglomerate or a racemic compound based on the different crystallization conditions. One racemic conglomerate and one racemic compound were disclosed and characterized in this research. Efonidipine conglomerate could obtain from its racemic solution when ethanol, methanol, tetrahydrofuran, ethyl acetate and acetonitrile were chosen as the crystallized solvent. While, racemic compound which existed as an acetone solvate could be prepared by crystallization from acetone only and the crystallization process must be keep stood without agitating. In order to confirm this conclusion, three single crystals of R-efonidipine, S-efonidipine and R/S- efonidipine acetone solvate have been prepared and determined.

Copyright

© 2017, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Linyuan ZHU
AU  - Zhanjun LI
AU  - Yuzhen YU
AU  - Wen LI
PY  - 2016/12
DA  - 2016/12
TI  - Crystallization of the Racemic Conglomerate and Racemic Compound of Efonidipine
BT  - Proceedings of the 2016 International Conference on Biological Engineering and Pharmacy (BEP 2016)
PB  - Atlantis Press
SP  - 210
EP  - 214
SN  - 2468-5747
UR  - https://doi.org/10.2991/bep-16.2017.44
DO  - 10.2991/bep-16.2017.44
ID  - ZHU2016/12
ER  -