Proceedings of the 4th Borobudur International Symposium on Science and Technology 2022 (BIS-STE 2022)

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Effect of Extraction Solvent on Extraction Yield, Cytotoxic Activity and Bioactive Compound in Zingiber officinale Roscoe var rubrum

Authors
Kirana Anggraini1, *, Dyah Ayu Woro Setyaningrum1, Laela Wulansari1, 2, Hening Tyas Andayani3, Laviany Putri Shihran1, Isra Fauziyyah1
1Universitas Trisakti, Jakarta, Indonesia
2Tropical Biopharmaca Research Center, Institute for Research and Community Service (LPPM), IPB University, Bogor, Indonesia
3Fachärztin der Innere Medizin, Städtische Kliniken, Mönchengladbach, Germany
*Corresponding author. Email: kirana_anggraeni@trisakti.ac.id
Corresponding Author
Kirana Anggraini
Available Online 9 November 2023.
DOI
10.2991/978-94-6463-284-2_86How to use a DOI?
Keywords
Extraction Solvent; Cytotoxic Activity; Bioactive Compound; Zingiber officinale Roscoe var rubrum
Abstract

Red ginger (Zingiber officinale Roscoe var rubrum) is a commonly used spice in Indonesia. It contains various chemical constituents, such as phenolic compounds, terpenes, polysaccharides, lipids, organic acids, and fiber. The health benefits of ginger are mainly related to its phenolic compounds, such as gingerols and shogaols. 6-Gingerol has various biological properties including anticancer, antioxidant, anti-inflammatory, anti-platelet aggregation, and anti-fungal. The method used to obtain the red ginger extract was macerated using 30%, 70%, and 96% ethanols, n-hexane, ethyl acetate, and water. The research was started by testing the phytochemicals and water content of the simplicia. Furthermore, toxicity tests were carried out on each extract on shrimp larvae, and the determination of gingerol and shogaol levels was by High-Performance Liquid Chromatography. The results showed that the highest yield of red ginger extract was 12.1% in a water solvent. Phytochemical testing of red ginger simplicia contains saponins. The 96% ethanol extract had the highest cytotoxic activity with an LC50 value of -79.516 ppm. The highest contents of 6-gingerol, 8-gingerol, 10-gingerol, and 6-shogaol were found in n-hexane solvents, respectively 123.07 mg/g; 26.39 mg/g; 61.40 mg/g and 22.41 mg/g.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 4th Borobudur International Symposium on Science and Technology 2022 (BIS-STE 2022)
Series
Advances in Engineering Research
Publication Date
9 November 2023
ISBN
10.2991/978-94-6463-284-2_86
ISSN
2352-5401
DOI
10.2991/978-94-6463-284-2_86How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Kirana Anggraini
AU  - Dyah Ayu Woro Setyaningrum
AU  - Laela Wulansari
AU  - Hening Tyas Andayani
AU  - Laviany Putri Shihran
AU  - Isra Fauziyyah
PY  - 2023
DA  - 2023/11/09
TI  - Effect of Extraction Solvent on Extraction Yield, Cytotoxic Activity and Bioactive Compound in Zingiber officinale Roscoe var rubrum
BT  - Proceedings of the 4th Borobudur International Symposium on Science and Technology 2022 (BIS-STE 2022)
PB  - Atlantis Press
SP  - 815
EP  - 825
SN  - 2352-5401
UR  - https://doi.org/10.2991/978-94-6463-284-2_86
DO  - 10.2991/978-94-6463-284-2_86
ID  - Anggraini2023
ER  -