Coagulation Factor XII –A Key Pro-Inflammatory and Pro-Coagulant Protein
- Shan-Shan Wang, Jin-Wen Ge, Shao-Wu Cheng
- Corresponding Author
- Shan-Shan Wang
Available Online January 2016.
- https://doi.org/10.2991/bst-16.2016.13How to use a DOI?
- Coagulation factor XII, Inflammatory, Coagulation, Thrombosis.
- Coagulation factor XII (FXII) is a multidomain serine protease that is the starter of intrinsic coagulation pathway. FXII deficiency and clinical hemostasis are not associated with bleeding, so investigators have not considered FXII important in physiology for a long time. In seeking explanation for FXII-independent physiologic hemostasis, investigators found FXII is an essential constitute of contact system that mediates procoagulation and proinflammatory via the intrinsic coagulation pathway or the Kallikrein-kinin system, respectively. Date obtained in infectious inflammation have revealed FXII mediated clotting that limited bacterial or toxin spread in early phases, and regulated fibrinolysis in later. Moreover, FXII mediated two non-infectious inflammation Hereditary angioedema (HAE) and non-specific allergy via bradykinin (BK) formation. In the coagulation, thrombosis not only is involved with coagulation, but is redefined as thrombo-inflammatory disorder. This paper reviews in detail the progresses in roles of FXII intersection between inflammation and coagulation.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Shan-Shan Wang AU - Jin-Wen Ge AU - Shao-Wu Cheng PY - 2016/01 DA - 2016/01 TI - Coagulation Factor XII –A Key Pro-Inflammatory and Pro-Coagulant Protein BT - The International Conference on Biological Sciences and Technology PB - Atlantis Press SN - 2468-5747 UR - https://doi.org/10.2991/bst-16.2016.13 DO - https://doi.org/10.2991/bst-16.2016.13 ID - Wang2016/01 ER -