Coagulation Factor XII –A Key Pro-Inflammatory and Pro-Coagulant Protein

DOI

10.2991/bst-16.2016.13How to use a DOI?

Keywords

Coagulation factor XII, Inflammatory, Coagulation, Thrombosis.

Abstract

Coagulation factor XII (FXII) is a multidomain serine protease that is the starter of intrinsic coagulation pathway. FXII deficiency and clinical hemostasis are not associated with bleeding, so investigators have not considered FXII important in physiology for a long time. In seeking explanation for FXII-independent physiologic hemostasis, investigators found FXII is an essential constitute of contact system that mediates procoagulation and proinflammatory via the intrinsic coagulation pathway or the Kallikrein-kinin system, respectively. Date obtained in infectious inflammation have revealed FXII mediated clotting that limited bacterial or toxin spread in early phases, and regulated fibrinolysis in later. Moreover, FXII mediated two non-infectious inflammation Hereditary angioedema (HAE) and non-specific allergy via bradykinin (BK) formation. In the coagulation, thrombosis not only is involved with coagulation, but is redefined as thrombo-inflammatory disorder. This paper reviews in detail the progresses in roles of FXII intersection between inflammation and coagulation.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Shan-Shan Wang
AU  - Jin-Wen Ge
AU  - Shao-Wu Cheng
PY  - 2016/01
DA  - 2016/01
TI  - Coagulation Factor XII –A Key Pro-Inflammatory and Pro-Coagulant Protein
BT  - Proceedings of the 2016 International Conference on Biological Sciences and Technology
PB  - Atlantis Press
SP  - 79
EP  - 84
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-16.2016.13
DO  - 10.2991/bst-16.2016.13
ID  - Wang2016/01
ER  -