Proceedings of the 2016 International Conference on Biological Sciences and Technology

Analgesic Contrast of Diverse Administrations of Botulinum Neurotoxin A (BoTN/A) Using Rat Neuropathic Pain Model

Authors
Qiong-Fang Yang, Li-Zu Xiao, Wei-Jiao Xie, Yun-Hai Qiu
Corresponding Author
Qiong-Fang Yang
Available Online January 2016.
DOI
https://doi.org/10.2991/bst-16.2016.38How to use a DOI?
Keywords
Botulinum Neurotoxin A, Neuropathic Pain, Administration.
Abstract
As a widely used clinical biomedicine for movement disorders and anti-wrinkle, in recent years, BoTN/A has emerged as a potential approach for treating refractory pain, especially migraine, diabetic pain, postherpetic neuralgia (PHN). In this study, we compared the analgesic effect of diverse administrations of Botulinum neurotoxin A (BoTN/A) on rat partial sciatic nerve ligation (PSNL) neuropathic pain model. Single intraplantar (i.pl.) and intrathecal (i.t.) injection of BoTN/A was applied after or before PSNL operation, respectively. The nociceptive behavioral tests showed single intraplantar injection after or before operation, limitedly blocked PSNL induced mechanical and thermal hypersensitivity, even at quite high dose (40U/kg). However, single BoTN/A intrathecal injection low dose (1U/kg) at 2 days previous operation, prevented the neuropathic pain initiation and facilitated functional recovery. These results indicated intrathecal pre-administration of BoTN/A has opportunity to be approved as preventive medication in clinical application.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Proceedings
The International Conference on Biological Sciences and Technology
Part of series
Advances in Biological Sciences Research
Publication Date
January 2016
ISBN
978-94-6252-161-2
ISSN
2468-5747
DOI
https://doi.org/10.2991/bst-16.2016.38How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Qiong-Fang Yang
AU  - Li-Zu Xiao
AU  - Wei-Jiao Xie
AU  - Yun-Hai Qiu
PY  - 2016/01
DA  - 2016/01
TI  - Analgesic Contrast of Diverse Administrations of Botulinum Neurotoxin A (BoTN/A) Using Rat Neuropathic Pain Model
BT  - The International Conference on Biological Sciences and Technology
PB  - Atlantis Press
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-16.2016.38
DO  - https://doi.org/10.2991/bst-16.2016.38
ID  - Yang2016/01
ER  -