Analgesic Contrast of Diverse Administrations of Botulinum Neurotoxin A (BoTN/A) Using Rat Neuropathic Pain Model
- Qiong-Fang Yang, Li-Zu Xiao, Wei-Jiao Xie, Yun-Hai Qiu
- Corresponding Author
- Qiong-Fang Yang
Available Online January 2016.
- https://doi.org/10.2991/bst-16.2016.38How to use a DOI?
- Botulinum Neurotoxin A, Neuropathic Pain, Administration.
- As a widely used clinical biomedicine for movement disorders and anti-wrinkle, in recent years, BoTN/A has emerged as a potential approach for treating refractory pain, especially migraine, diabetic pain, postherpetic neuralgia (PHN). In this study, we compared the analgesic effect of diverse administrations of Botulinum neurotoxin A (BoTN/A) on rat partial sciatic nerve ligation (PSNL) neuropathic pain model. Single intraplantar (i.pl.) and intrathecal (i.t.) injection of BoTN/A was applied after or before PSNL operation, respectively. The nociceptive behavioral tests showed single intraplantar injection after or before operation, limitedly blocked PSNL induced mechanical and thermal hypersensitivity, even at quite high dose (40U/kg). However, single BoTN/A intrathecal injection low dose (1U/kg) at 2 days previous operation, prevented the neuropathic pain initiation and facilitated functional recovery. These results indicated intrathecal pre-administration of BoTN/A has opportunity to be approved as preventive medication in clinical application.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Qiong-Fang Yang AU - Li-Zu Xiao AU - Wei-Jiao Xie AU - Yun-Hai Qiu PY - 2016/01 DA - 2016/01 TI - Analgesic Contrast of Diverse Administrations of Botulinum Neurotoxin A (BoTN/A) Using Rat Neuropathic Pain Model BT - The International Conference on Biological Sciences and Technology PB - Atlantis Press SN - 2468-5747 UR - https://doi.org/10.2991/bst-16.2016.38 DO - https://doi.org/10.2991/bst-16.2016.38 ID - Yang2016/01 ER -