Analgesic Contrast of Diverse Administrations of Botulinum Neurotoxin A (BoTN/A) Using Rat Neuropathic Pain Model

DOI

10.2991/bst-16.2016.38How to use a DOI?

Keywords

Botulinum Neurotoxin A, Neuropathic Pain, Administration.

Abstract

As a widely used clinical biomedicine for movement disorders and anti-wrinkle, in recent years, BoTN/A has emerged as a potential approach for treating refractory pain, especially migraine, diabetic pain, postherpetic neuralgia (PHN). In this study, we compared the analgesic effect of diverse administrations of Botulinum neurotoxin A (BoTN/A) on rat partial sciatic nerve ligation (PSNL) neuropathic pain model. Single intraplantar (i.pl.) and intrathecal (i.t.) injection of BoTN/A was applied after or before PSNL operation, respectively. The nociceptive behavioral tests showed single intraplantar injection after or before operation, limitedly blocked PSNL induced mechanical and thermal hypersensitivity, even at quite high dose (40U/kg). However, single BoTN/A intrathecal injection low dose (1U/kg) at 2 days previous operation, prevented the neuropathic pain initiation and facilitated functional recovery. These results indicated intrathecal pre-administration of BoTN/A has opportunity to be approved as preventive medication in clinical application.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Qiong-Fang Yang
AU  - Li-Zu Xiao
AU  - Wei-Jiao Xie
AU  - Yun-Hai Qiu
PY  - 2016/01
DA  - 2016/01
TI  - Analgesic Contrast of Diverse Administrations of Botulinum Neurotoxin A (BoTN/A) Using Rat Neuropathic Pain Model
BT  - Proceedings of the 2016 International Conference on Biological Sciences and Technology
PB  - Atlantis Press
SP  - 256
EP  - 262
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-16.2016.38
DO  - 10.2991/bst-16.2016.38
ID  - Yang2016/01
ER  -