Proceedings of the 2016 International Conference on Biological Sciences and Technology

Altered Anatomical Modular Organization of Brain Networks in Patients with Major Depressive Disorder

Authors
Jing-Yu Zhu, Xiang-Yu Shen, Jiao-Long Qin, Mao-Bin Wei, Rui Yan, Jian-Huai Chen, Zhi-Jian Yao, Qing Lu
Corresponding Author
Jing-Yu Zhu
Available Online January 2016.
DOI
https://doi.org/10.2991/bst-16.2016.42How to use a DOI?
Keywords
Major depressive disorder, Modular organization, Structural connectivity.
Abstract
This study investigates the abnormal brain structural connectivity in patients with major depressive disorder (MDD) through a modularization approach. Diffusion tensor imaging (DTI) data were collected from 20 MDD patients and 20 age-matched controls. The structural modularity characteristics and their relationships with clinical variables were examined. Results indicated that MDD patients exhibited reorganized modules with widely damaged global inter-module connectivity in limbic system and altered intra-module connectivity in left hemisphere. Furthermore, the module degree in right rolandic operculum, left posterior cingulate gyrus, right cuneus and right fusiform gyrus were negatively correlated with the depression severity. Additionally, a positive relationship was also found between the duration of disease and participant coefficient in left median cingulate. The current findings highlight altered modular organization in MDD patients, which might contribute to the pathogenesis of the disease.
Open Access
This is an open access article distributed under the CC BY-NC license.

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Proceedings
The International Conference on Biological Sciences and Technology
Part of series
Advances in Biological Sciences Research
Publication Date
January 2016
ISBN
978-94-6252-161-2
ISSN
2468-5747
DOI
https://doi.org/10.2991/bst-16.2016.42How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Jing-Yu Zhu
AU  - Xiang-Yu Shen
AU  - Jiao-Long Qin
AU  - Mao-Bin Wei
AU  - Rui Yan
AU  - Jian-Huai Chen
AU  - Zhi-Jian Yao
AU  - Qing Lu
PY  - 2016/01
DA  - 2016/01
TI  - Altered Anatomical Modular Organization of Brain Networks in Patients with Major Depressive Disorder
BT  - The International Conference on Biological Sciences and Technology
PB  - Atlantis Press
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-16.2016.42
DO  - https://doi.org/10.2991/bst-16.2016.42
ID  - Zhu2016/01
ER  -