Altered Anatomical Modular Organization of Brain Networks in Patients with Major Depressive Disorder
- Jing-Yu Zhu, Xiang-Yu Shen, Jiao-Long Qin, Mao-Bin Wei, Rui Yan, Jian-Huai Chen, Zhi-Jian Yao, Qing Lu
- Corresponding Author
- Jing-Yu Zhu
Available Online January 2016.
- https://doi.org/10.2991/bst-16.2016.42How to use a DOI?
- Major depressive disorder, Modular organization, Structural connectivity.
- This study investigates the abnormal brain structural connectivity in patients with major depressive disorder (MDD) through a modularization approach. Diffusion tensor imaging (DTI) data were collected from 20 MDD patients and 20 age-matched controls. The structural modularity characteristics and their relationships with clinical variables were examined. Results indicated that MDD patients exhibited reorganized modules with widely damaged global inter-module connectivity in limbic system and altered intra-module connectivity in left hemisphere. Furthermore, the module degree in right rolandic operculum, left posterior cingulate gyrus, right cuneus and right fusiform gyrus were negatively correlated with the depression severity. Additionally, a positive relationship was also found between the duration of disease and participant coefficient in left median cingulate. The current findings highlight altered modular organization in MDD patients, which might contribute to the pathogenesis of the disease.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Jing-Yu Zhu AU - Xiang-Yu Shen AU - Jiao-Long Qin AU - Mao-Bin Wei AU - Rui Yan AU - Jian-Huai Chen AU - Zhi-Jian Yao AU - Qing Lu PY - 2016/01 DA - 2016/01 TI - Altered Anatomical Modular Organization of Brain Networks in Patients with Major Depressive Disorder BT - The International Conference on Biological Sciences and Technology PB - Atlantis Press SN - 2468-5747 UR - https://doi.org/10.2991/bst-16.2016.42 DO - https://doi.org/10.2991/bst-16.2016.42 ID - Zhu2016/01 ER -