Altered Anatomical Modular Organization of Brain Networks in Patients with Major Depressive Disorder

DOI

10.2991/bst-16.2016.42How to use a DOI?

Keywords

Major depressive disorder, Modular organization, Structural connectivity.

Abstract

This study investigates the abnormal brain structural connectivity in patients with major depressive disorder (MDD) through a modularization approach. Diffusion tensor imaging (DTI) data were collected from 20 MDD patients and 20 age-matched controls. The structural modularity characteristics and their relationships with clinical variables were examined. Results indicated that MDD patients exhibited reorganized modules with widely damaged global inter-module connectivity in limbic system and altered intra-module connectivity in left hemisphere. Furthermore, the module degree in right rolandic operculum, left posterior cingulate gyrus, right cuneus and right fusiform gyrus were negatively correlated with the depression severity. Additionally, a positive relationship was also found between the duration of disease and participant coefficient in left median cingulate. The current findings highlight altered modular organization in MDD patients, which might contribute to the pathogenesis of the disease.

Copyright

© 2016, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Jing-Yu Zhu
AU  - Xiang-Yu Shen
AU  - Jiao-Long Qin
AU  - Mao-Bin Wei
AU  - Rui Yan
AU  - Jian-Huai Chen
AU  - Zhi-Jian Yao
AU  - Qing Lu
PY  - 2016/01
DA  - 2016/01
TI  - Altered Anatomical Modular Organization of Brain Networks in Patients with Major Depressive Disorder
BT  - Proceedings of the 2016 International Conference on Biological Sciences and Technology
PB  - Atlantis Press
SP  - 284
EP  - 289
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-16.2016.42
DO  - 10.2991/bst-16.2016.42
ID  - Zhu2016/01
ER  -