MRS and DTI Study in Cognitive Deficit in Patients with Type 2 Diabetes Mellitus

DOI

10.2991/bst-17.2018.12How to use a DOI?

Keywords

Diabetes type 2(DM2), Cognitive function, Diffusion tensor imaging (DTI), 1H magnetic resonance spectroscopy (MRS).

Abstract

To investigate the cognitive function in patients with type 2 diabetes mellitus (T2DM) by 1H magnetic resonance spectroscopy (MRS) and diffusion tensor imaging (DTI). We studied forty-one patients with T2DM and the other group of thirty-five healthy control subjects by MRS and DTI. A region of interest (ROI) was positioned in the white matter of the centrum semiovale. The results indicated that the mean of the ratio of NAA to Cr(NAA/Cr), the ratio of NAA to Cho(NAA/Cho), and the FA values decreased, while the ADC values increased in the diabetic patients (P<0.01, all). Both of the mean in NAA/Cr and the ratio of Cho to Cr(Cho/Cr) showed strong correlation to FA values in diabetic patients (r=0.603 and r= 0.646; P<0.01, both). The FA values also correlated significantly with Mini-Mental State Examination (MMSE) (r=0.568; P<0.01). The relationship of Cho and NAA to the FA values, and thus to the content of neuronal structures in patients with T2DM, suggests that these metabolic changes are consistent with axonal loss or dysfunction. Diffusion tensor measurement is more effectively in monitoring the progression of the cognitive impairment in diabetic.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Lan-Mei Chen
AU  - Yuan Xu
AU  - Hai-Du Zhang
AU  - Wen-Bin Zheng
PY  - 2018/02
DA  - 2018/02
TI  - MRS and DTI Study in Cognitive Deficit in Patients with Type 2 Diabetes Mellitus
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 74
EP  - 79
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.12
DO  - 10.2991/bst-17.2018.12
ID  - Chen2018/02
ER  -