Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)

Synthesis of Diethyl 2-(2-chloronicotinoyl)malonate

Authors
He-Hua Xiong, Yong-Li Duan, Shuang Jia, Ding-Ling Shi, Zhi-Min Li, Qi-Dong Tang
Corresponding Author
He-Hua Xiong
Available Online February 2018.
DOI
https://doi.org/10.2991/bst-17.2018.39How to use a DOI?
Keywords
Diethyl 2-(2-chloronicotinoyl)malonate, Synthesis.
Abstract

Diethyl 2-(2-chloronicotinoyl)malonate 3 is a nitrogen-containing water-soluble carboxylic acid as an important intermediates of small molecule anticancer drugs. In this study, this paper explored a faster and celerity method to synthesize compound 3. By using 2-chloronicotinic acid as a kind of easily available compound through two steps to made the target compound. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the two steps was 83.3 %.

Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
Series
Advances in Biological Sciences Research
Publication Date
February 2018
ISBN
978-94-6252-472-9
ISSN
2468-5747
DOI
https://doi.org/10.2991/bst-17.2018.39How to use a DOI?
Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - He-Hua Xiong
AU  - Yong-Li Duan
AU  - Shuang Jia
AU  - Ding-Ling Shi
AU  - Zhi-Min Li
AU  - Qi-Dong Tang
PY  - 2018/02
DA  - 2018/02
TI  - Synthesis of Diethyl 2-(2-chloronicotinoyl)malonate
BT  - Proceedings of the 2017 2nd International Conference on Biological Sciences and Technology (BST 2017)
PB  - Atlantis Press
SP  - 255
EP  - 258
SN  - 2468-5747
UR  - https://doi.org/10.2991/bst-17.2018.39
DO  - https://doi.org/10.2991/bst-17.2018.39
ID  - Xiong2018/02
ER  -