Allopurinol Administration: When is More Effective?

DOI

10.2991/ahsr.k.200523.077How to use a DOI?

Keywords

allopurinol, uric acid, hyperuricemia

Abstract

Objectives: The objective of the study was to determine the appropriate administration time of allopurinol between morning and night administration. Method: This research was conducted in a controlled and open label. Eleven patients (six in night and five in morning) were fulfilled the criteria. Results and Discussion: no significant difference in the uric acid reduction between night and morning administration (p 0.435). However, night administration of allopurinol showed lower uric acid level reduction (-2.45 vs -0.98). In adverse reactions events, the night administration of allopurinol contributed to nausea and flatulence. Conclusion: Allopurinol provides better uric acid reduction at night but should be caution of the side effects.

Copyright

© 2020, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Yedy Purwandi Sukmawan
AU  - Keni Idacahyati
AU  - Wina Widiyanti
PY  - 2020
DA  - 2020/06/08
TI  - Allopurinol Administration: When is More Effective?
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 324
EP  - 325
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.077
DO  - 10.2991/ahsr.k.200523.077
ID  - Sukmawan2020
ER  -