Hepatoprotector Effect of Papaya (Carica Papaya L.) Ethanol Extract on Male Wistar Rats Induced by Acetaminophen
- 10.2991/ahsr.k.200523.017How to use a DOI?
- ethanol extract of papaya (Carica papaya L.), hepatoprotector, acetaminophen, SGOT, SGPT
Hepatoprotector compound can provide liver protection to the liver from damage caused by drugs, chemical compounds and viruses. This study was aim to determine the hepatoprotector effect of several doses of papaya (Carica papaya L.) ethanol extract in acetamnophen-induced rats. This research was an experimental research. 25 rats were randomly divided into five treatment groups: normal group, negative control (acetaminophen 250 mg / kg body weight), dose 1 (6.95 mg / 200 gram rats weight), dose 2 (13.9 mg / 200 gram rats weight), and dose 3 (27.8 mg / 200 gram rats weight). Papaya (Carica papaya L.) ethanol extract was given for 7 days. 2 hours after the 7th day of the research, the male white rats were induced by acetaminophen. SGOT and SGPT levels measurement was performed on day 8. Data were analyzed using One-way anova followed by LSD. SGOT and SGPT parameters, showed significant differences between negative control compared normal group, dose 2 and dose 3. SGOT and SGPT levels found to be decreasing nearing normal at dose 2. Based on this data, papaya (Carica papaya L.) has the most effective on dose 2 (13.9 mg / 200gram BB).
- © 2020, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Helni Nopelia AU - Ilham Alifiar AU - Maritsa Nurfatwa PY - 2020 DA - 2020/06/08 TI - Hepatoprotector Effect of Papaya (Carica Papaya L.) Ethanol Extract on Male Wistar Rats Induced by Acetaminophen BT - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019) PB - Atlantis Press SP - 61 EP - 66 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.200523.017 DO - 10.2991/ahsr.k.200523.017 ID - Nopelia2020 ER -