The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)

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Hepatoprotector Effect of Papaya (Carica Papaya L.) Ethanol Extract on Male Wistar Rats Induced by Acetaminophen

Authors
Helni Nopelia, Ilham Alifiar, Maritsa Nurfatwa
Corresponding Author
Helni Nopelia
Available Online 8 June 2020.
DOI
10.2991/ahsr.k.200523.017How to use a DOI?
Keywords
ethanol extract of papaya (Carica papaya L.), hepatoprotector, acetaminophen, SGOT, SGPT
Abstract

Hepatoprotector compound can provide liver protection to the liver from damage caused by drugs, chemical compounds and viruses. This study was aim to determine the hepatoprotector effect of several doses of papaya (Carica papaya L.) ethanol extract in acetamnophen-induced rats. This research was an experimental research. 25 rats were randomly divided into five treatment groups: normal group, negative control (acetaminophen 250 mg / kg body weight), dose 1 (6.95 mg / 200 gram rats weight), dose 2 (13.9 mg / 200 gram rats weight), and dose 3 (27.8 mg / 200 gram rats weight). Papaya (Carica papaya L.) ethanol extract was given for 7 days. 2 hours after the 7th day of the research, the male white rats were induced by acetaminophen. SGOT and SGPT levels measurement was performed on day 8. Data were analyzed using One-way anova followed by LSD. SGOT and SGPT parameters, showed significant differences between negative control compared normal group, dose 2 and dose 3. SGOT and SGPT levels found to be decreasing nearing normal at dose 2. Based on this data, papaya (Carica papaya L.) has the most effective on dose 2 (13.9 mg / 200gram BB).

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
Series
Advances in Health Sciences Research
Publication Date
8 June 2020
ISBN
10.2991/ahsr.k.200523.017
ISSN
2468-5739
DOI
10.2991/ahsr.k.200523.017How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Helni Nopelia
AU  - Ilham Alifiar
AU  - Maritsa Nurfatwa
PY  - 2020
DA  - 2020/06/08
TI  - Hepatoprotector Effect of Papaya (Carica Papaya L.) Ethanol Extract on Male Wistar Rats Induced by Acetaminophen
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 61
EP  - 66
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.017
DO  - 10.2991/ahsr.k.200523.017
ID  - Nopelia2020
ER  -