The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)

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Pharmaceutical Cocrystal of Ethyl p-Methoxycinnamate: Formulation and Characterization

Authors
Revika Rachmaniar, Sohadi Warya, Rival Ferdiansyah, Hesti Riasari, Aswin Gumelar, Kenti
Corresponding Author
Revika Rachmaniar
Available Online 8 June 2020.
DOI
10.2991/ahsr.k.200523.024How to use a DOI?
Keywords
ethyl p-methoxycinnamate, tartaric acid, cocrystals
Abstract

Ethyl p-methoxycinamate (EPMC) is a compound derived from kencur (Kaemferia galanga) and has a pharmacological effect as an antiinflammatory. EPMC has poorly water solubility and need to be modified to increase its solubility. The aim of this study was to improve the water solubility of EPMC by cocrystallization method. Cocrystal formation between EPMC and tartaric acid as a coformer with various ratio of 1:1, 1:2, and 1:3 were produced by solvent drop grinding technique utilizing methanol solvent. EPMC-tartaric acid cocrystal were characterized by fourier transform Infrared (FTIR) spectrophotometer, X-ray diffraction (XRD), scanning electron microscopy (SEM), and water solubility study. The result showed that the EPMC- tartaric acid cocrystal have new diffraction and changing in peak intensity of crystallinity and aggregation occurs, but the cocrystallization did not damage the particles. The water solubility of EPMC-TA cocrystals ratio of 1:1, 1:2, and 1:3 increased 1.39; 1.50; 1.44 folds respectively. It could be concluded that cocrystal formation succeeded increase solubility of EPMC by utilizing solvent drop grinding as technique, tartaric acid as coformer, and methanol as solvent.

Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
Series
Advances in Health Sciences Research
Publication Date
8 June 2020
ISBN
10.2991/ahsr.k.200523.024
ISSN
2468-5739
DOI
10.2991/ahsr.k.200523.024How to use a DOI?
Copyright
© 2020, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Revika Rachmaniar
AU  - Sohadi Warya
AU  - Rival Ferdiansyah
AU  - Hesti Riasari
AU  - Aswin Gumelar
AU  - Kenti
PY  - 2020
DA  - 2020/06/08
TI  - Pharmaceutical Cocrystal of Ethyl p-Methoxycinnamate: Formulation and Characterization
BT  - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019)
PB  - Atlantis Press
SP  - 96
EP  - 101
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.200523.024
DO  - 10.2991/ahsr.k.200523.024
ID  - Rachmaniar2020
ER  -