Pharmaceutical Cocrystal of Ethyl p-Methoxycinnamate: Formulation and Characterization
- 10.2991/ahsr.k.200523.024How to use a DOI?
- ethyl p-methoxycinnamate, tartaric acid, cocrystals
Ethyl p-methoxycinamate (EPMC) is a compound derived from kencur (Kaemferia galanga) and has a pharmacological effect as an antiinflammatory. EPMC has poorly water solubility and need to be modified to increase its solubility. The aim of this study was to improve the water solubility of EPMC by cocrystallization method. Cocrystal formation between EPMC and tartaric acid as a coformer with various ratio of 1:1, 1:2, and 1:3 were produced by solvent drop grinding technique utilizing methanol solvent. EPMC-tartaric acid cocrystal were characterized by fourier transform Infrared (FTIR) spectrophotometer, X-ray diffraction (XRD), scanning electron microscopy (SEM), and water solubility study. The result showed that the EPMC- tartaric acid cocrystal have new diffraction and changing in peak intensity of crystallinity and aggregation occurs, but the cocrystallization did not damage the particles. The water solubility of EPMC-TA cocrystals ratio of 1:1, 1:2, and 1:3 increased 1.39; 1.50; 1.44 folds respectively. It could be concluded that cocrystal formation succeeded increase solubility of EPMC by utilizing solvent drop grinding as technique, tartaric acid as coformer, and methanol as solvent.
- © 2020, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Revika Rachmaniar AU - Sohadi Warya AU - Rival Ferdiansyah AU - Hesti Riasari AU - Aswin Gumelar AU - Kenti PY - 2020 DA - 2020/06/08 TI - Pharmaceutical Cocrystal of Ethyl p-Methoxycinnamate: Formulation and Characterization BT - The proceedings of the 2nd Bakti Tunas Husada-Health Science International Conference (BTH-HSIC 2019) PB - Atlantis Press SP - 96 EP - 101 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.200523.024 DO - 10.2991/ahsr.k.200523.024 ID - Rachmaniar2020 ER -