Proceedings of the 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)

Synthesis of tert-butyl 5-amino-4 - ((2- (dimethylamino) ethyl) (methyl) amino) -2- methoxyphenyl) Carbamate

Authors
Bingbing Zhao, Yuping Guo, Zhou Lan, Shan Xu
Corresponding Author
Bingbing Zhao
Available Online February 2017.
DOI
https://doi.org/10.2991/emcm-16.2017.41How to use a DOI?
Keywords
4-Fluoro-2-methoxy-5-nitroaniline; Tert-Butyl 5-amino-4 - ((2-(dimethyl- amino) ethyl) (methyl) amino) -2- methoxyphenyl) carbamate; Synthesis
Abstract
Tert-Butyl 5-amino-4 - ((2-(dimethyl- amino) ethyl) (methyl) amino) -2- methoxyphenyl) carbamate (1) is an important intermediate in many biologically active compounds such as omisertinib (AZD9291). In this work, a rapid synthetic method for compound 1 was established. The compound 1 was synthesized from the commercially available 4-fluoro-2- methoxy-5- nitroaniline through three steps including acylation, nucleophilic substitution and reduction. The structures were confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized, and the total yield of the three steps was 81 %.
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Proceedings
2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
Part of series
Advances in Computer Science Research
Publication Date
February 2017
ISBN
978-94-6252-297-8
ISSN
2352-538X
DOI
https://doi.org/10.2991/emcm-16.2017.41How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Bingbing Zhao
AU  - Yuping Guo
AU  - Zhou Lan
AU  - Shan Xu
PY  - 2017/02
DA  - 2017/02
TI  - Synthesis of tert-butyl 5-amino-4 - ((2- (dimethylamino) ethyl) (methyl) amino) -2- methoxyphenyl) Carbamate
BT  - 2016 7th International Conference on Education, Management, Computer and Medicine (EMCM 2016)
PB  - Atlantis Press
SP  - 210
EP  - 213
SN  - 2352-538X
UR  - https://doi.org/10.2991/emcm-16.2017.41
DO  - https://doi.org/10.2991/emcm-16.2017.41
ID  - Zhao2017/02
ER  -