Proceedings of the 3rd Green Development International Conference (GDIC 2020)

Acute Toxicity Study of Durian Mesocarpium Ethanol Extracts (Durio Zibethinus Linn) in Healthy Mice

Authors
Fitrianingsih, Sani K Fathnur, Diah Tri Utami
Corresponding Author
Fitrianingsih
Available Online 26 August 2021.
DOI
10.2991/aer.k.210825.054How to use a DOI?
Keywords
Acute Toxicity, Durian Mesocarpium, Ethanol Extracts, LD50
Abstract

Durian (Durio zibethinus Linn.) has been shown to have toxicity effect on acute toxicity in vivo. Objective: This study aimed to determine the acute toxicity of the Durian Mesocarpium Ethanol Extracts (EEMD), various doses of Durian Mesocarpium Ethanol Extracts (EEMD) by examining in vivo to the healthy mice experimentally. The toxic effects appeared in a short time after 24 hours by oral administrations of the dosages. This study used completely randomized design. The animals used in this study were mice (Swiss Webster), with criteria are healthy, male, and the range of the ages were 2 – 3 months with the body weight 20 – 30 g. The various dosages of Durian Mesocarpium Ethanol Extracts (EEMD) were divided into six experimental groups to determine the LD50 there are K- (NaCMC); P1 (100 mg/KgBW); P2 (200 mg/KgBW); P3 (400 mg/KgBW); P4 (800 mg/KgBW); P5 (1600 mg/KgBW). The result showed that Durian Mesocarpium Ethanol Extracts (EEMD) has LD50 400 mg/KgBW which included in moderate toxicity with effect like tremor which is one of type acute toxicity due to healthy mice. Conclusion: Based on these results, Durian (Durio zibethinus Linn.) have moderate toxicity after 24 hours oral administration dosages.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 3rd Green Development International Conference (GDIC 2020)
Series
Advances in Engineering Research
Publication Date
26 August 2021
ISBN
10.2991/aer.k.210825.054
ISSN
2352-5401
DOI
10.2991/aer.k.210825.054How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Fitrianingsih
AU  - Sani K Fathnur
AU  - Diah Tri Utami
PY  - 2021
DA  - 2021/08/26
TI  - Acute Toxicity Study of Durian Mesocarpium Ethanol Extracts (Durio Zibethinus Linn) in Healthy Mice
BT  - Proceedings of the 3rd Green Development International Conference (GDIC 2020)
PB  - Atlantis Press
SP  - 305
EP  - 308
SN  - 2352-5401
UR  - https://doi.org/10.2991/aer.k.210825.054
DO  - 10.2991/aer.k.210825.054
ID  - 2021
ER  -