Acute Toxicity Study of Durian Mesocarpium Ethanol Extracts (Durio Zibethinus Linn) in Healthy Mice
- 10.2991/aer.k.210825.054How to use a DOI?
- Acute Toxicity, Durian Mesocarpium, Ethanol Extracts, LD50
Durian (Durio zibethinus Linn.) has been shown to have toxicity effect on acute toxicity in vivo. Objective: This study aimed to determine the acute toxicity of the Durian Mesocarpium Ethanol Extracts (EEMD), various doses of Durian Mesocarpium Ethanol Extracts (EEMD) by examining in vivo to the healthy mice experimentally. The toxic effects appeared in a short time after 24 hours by oral administrations of the dosages. This study used completely randomized design. The animals used in this study were mice (Swiss Webster), with criteria are healthy, male, and the range of the ages were 2 – 3 months with the body weight 20 – 30 g. The various dosages of Durian Mesocarpium Ethanol Extracts (EEMD) were divided into six experimental groups to determine the LD50 there are K- (NaCMC); P1 (100 mg/KgBW); P2 (200 mg/KgBW); P3 (400 mg/KgBW); P4 (800 mg/KgBW); P5 (1600 mg/KgBW). The result showed that Durian Mesocarpium Ethanol Extracts (EEMD) has LD50 400 mg/KgBW which included in moderate toxicity with effect like tremor which is one of type acute toxicity due to healthy mice. Conclusion: Based on these results, Durian (Durio zibethinus Linn.) have moderate toxicity after 24 hours oral administration dosages.
- © 2021, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Fitrianingsih AU - Sani K Fathnur AU - Diah Tri Utami PY - 2021 DA - 2021/08/26 TI - Acute Toxicity Study of Durian Mesocarpium Ethanol Extracts (Durio Zibethinus Linn) in Healthy Mice BT - Proceedings of the 3rd Green Development International Conference (GDIC 2020) PB - Atlantis Press SP - 305 EP - 308 SN - 2352-5401 UR - https://doi.org/10.2991/aer.k.210825.054 DO - 10.2991/aer.k.210825.054 ID - 2021 ER -