Synthesis of Quinazolinyl Chalcone Derivatives
Heping Yan, Jianguang Shi, Gaozhang Gou, Jucheng Zhang, Dushu Huang, Shijuan Xu, Xuebin Chen, Xuequan Wang, Yong Hong, Wei Liu
Available Online August 2015.
- https://doi.org/10.2991/ic3me-15.2015.61How to use a DOI?
- 2-aminobenzonitrile; N,N-dimethylformamide dimethyl acetal; aminoa- cetophenone; paradimethylaminobenzaldehyde; chalcone; quinazoline
- 4-(4'-quinazolin-ylamino) phenyl-4-(N,N- dimethylamino) phenyl propenyl ketone with total yield of 68.0% was synthesized with 2-aminobenzonitrile and N,N-dimethylformamide dimethyl acetal as a starting material, the synthesis of N-(2-cyanophenyl)-N,N-dimethyl formami- dine, and then amino acetophenone to form a ring, and finally reaction with formaldehyde dimethylaminobenzaldehyde. The experimental conditions were optimized. The results showed that: Intermediate 1 was synthesized by 2-aminobenzonitrile and N, N- dimethylformamide dimethyl acetal and their molar ratio of 1: 2, the optimal reaction temperature is 85 . Intermediate 2 synthesized optimal temperature of 105 . Intermediates and target compounds by 1H NMR, 13C NMR and mass spectrometry for structural characterization.
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Cite this article
TY - CONF AU - Heping Yan AU - Jianguang Shi AU - Gaozhang Gou AU - Jucheng Zhang AU - Dushu Huang AU - Shijuan Xu AU - Xuebin Chen AU - Xuequan Wang AU - Yong Hong AU - Wei Liu PY - 2015/08 DA - 2015/08 TI - Synthesis of Quinazolinyl Chalcone Derivatives BT - 3rd International Conference on Material, Mechanical and Manufacturing Engineering (IC3ME 2015) PB - Atlantis Press SN - 2352-5401 UR - https://doi.org/10.2991/ic3me-15.2015.61 DO - https://doi.org/10.2991/ic3me-15.2015.61 ID - Yan2015/08 ER -