Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering

Synthesis of Quinazolinyl Chalcone Derivatives

Authors
Heping Yan, Jianguang Shi, Gaozhang Gou, Jucheng Zhang, Dushu Huang, Shijuan Xu, Xuebin Chen, Xuequan Wang, Yong Hong, Wei Liu
Corresponding Author
Heping Yan
Available Online August 2015.
DOI
https://doi.org/10.2991/ic3me-15.2015.61How to use a DOI?
Keywords
2-aminobenzonitrile; N,N-dimethylformamide dimethyl acetal; aminoa- cetophenone; paradimethylaminobenzaldehyde; chalcone; quinazoline
Abstract
4-(4'-quinazolin-ylamino) phenyl-4-(N,N- dimethylamino) phenyl propenyl ketone with total yield of 68.0% was synthesized with 2-aminobenzonitrile and N,N-dimethylformamide dimethyl acetal as a starting material, the synthesis of N-(2-cyanophenyl)-N,N-dimethyl formami- dine, and then amino acetophenone to form a ring, and finally reaction with formaldehyde dimethylaminobenzaldehyde. The experimental conditions were optimized. The results showed that: Intermediate 1 was synthesized by 2-aminobenzonitrile and N, N- dimethylformamide dimethyl acetal and their molar ratio of 1: 2, the optimal reaction temperature is 85 . Intermediate 2 synthesized optimal temperature of 105 . Intermediates and target compounds by 1H NMR, 13C NMR and mass spectrometry for structural characterization.
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Proceedings
3rd International Conference on Material, Mechanical and Manufacturing Engineering (IC3ME 2015)
Part of series
Advances in Engineering Research
Publication Date
August 2015
ISBN
978-94-6252-100-1
ISSN
2352-5401
DOI
https://doi.org/10.2991/ic3me-15.2015.61How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Heping Yan
AU  - Jianguang Shi
AU  - Gaozhang Gou
AU  - Jucheng Zhang
AU  - Dushu Huang
AU  - Shijuan Xu
AU  - Xuebin Chen
AU  - Xuequan Wang
AU  - Yong Hong
AU  - Wei Liu
PY  - 2015/08
DA  - 2015/08
TI  - Synthesis of Quinazolinyl Chalcone Derivatives
BT  - 3rd International Conference on Material, Mechanical and Manufacturing Engineering (IC3ME 2015)
PB  - Atlantis Press
SN  - 2352-5401
UR  - https://doi.org/10.2991/ic3me-15.2015.61
DO  - https://doi.org/10.2991/ic3me-15.2015.61
ID  - Yan2015/08
ER  -