Synthesis and Biological Evaluation of the novel Antioxidant Agent Quercetin Derivatives
Authors
Xin Qu, Hongye Zhao, Dan Wu, Lianbo Zhao, Kui Lu, Yuou Teng
Corresponding Author
Xin Qu
Available Online August 2015.
- DOI
- 10.2991/ic3me-15.2015.100How to use a DOI?
- Keywords
- Quercetin, PC-12 cells, Antioxidant Activity
- Abstract
Three 3-substituted derivatives of quercetin were synthesized in 10-80% overall yields. Their structures were characterized by 1HNMR. Three target compounds (4a~4c) have not been reported before. The results showed that: pre-treated of PC-12 cells with, cell survival rate was higher than that of quercetin. In this project, the oxidative damage model of PC-12 cells was established and the antioxidant activities of three newly synthesized quercetin derivatives were evaluated. Among them, compound 4b (30 M) showed the highest antioxidant activity against H2O2. Cell viability in pre-treated with or without compound 4b (30 M) were 53.05% and 10.31%, higher than that of quercetin (47.22%).
- Copyright
- © 2015, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Xin Qu AU - Hongye Zhao AU - Dan Wu AU - Lianbo Zhao AU - Kui Lu AU - Yuou Teng PY - 2015/08 DA - 2015/08 TI - Synthesis and Biological Evaluation of the novel Antioxidant Agent Quercetin Derivatives BT - Proceedings of the 3rd International Conference on Material, Mechanical and Manufacturing Engineering PB - Atlantis Press SP - 505 EP - 509 SN - 2352-5401 UR - https://doi.org/10.2991/ic3me-15.2015.100 DO - 10.2991/ic3me-15.2015.100 ID - Qu2015/08 ER -