Effects of Batroxobin Injection on Progressive Ischemic Stroke and Serum MMP-2 and MMP-9 Expressions

DOI

10.2991/icaees-15.2015.164How to use a DOI?

Keywords

Batroxobin; Progressive ischemic stroke (PIS); MMP-2; MMP-9

Abstract

Effects of batroxobin on progressive ischemic stroke (PIS) and serum MMP-2 and MMP-9 expressions in patients with PIS were investigated. 160 Hospitalized patients with acute progressive ischemic stroke were randomly divided into a treatment group (n=80) and a control group (n=80). Patients in the treatment group were treated with the conventional therapy combined with batroxobin injection, in which 10u, 5u and 5u of batroxobin injection were successively administered once every other day, respectively, and patients in the control group were treated with the conventional therapy alone. Therapeutic effects on PIS and patients’ NIHSS scores between the two groups were compared. Serum MMP-2 and MMP-9 expressions before and after the treatment were detected with enzyme-linked immunosorbent assay (ELASE). The results showed that the total effective rate of patients in the treatment group was 91.25%, significantly better than that in the control group, which was 78.75% (P <0.05); NIHSS scores after the treatment were significantly lover than those before the treatment in both groups; compared with those before the treatment, MMP-2 and MMP-9 levels were significantly decreased after the treatment (P<0.05); differences in NIHSS scores and serum MMP-2 and MMP-9 levels between the two groups were significant after the treatment (P<0.05). Batroxobin injection can be used for the treatment of PIS, with a definite therapeutic effect. It is confirmed that batroxobin injection can significantly reduce the infarct area, promote the recovery of neurological functions, and delay the development of PIS to improve the prognosis of patients with PIS, which may be closely related to its reducing the level of MMP-2 and MMP-9 in the body.

Copyright

© 2015, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Weihai Jiang
AU  - Wei Sun
AU  - Shu Jing
PY  - 2015/07
DA  - 2015/07
TI  - Effects of Batroxobin Injection on Progressive Ischemic Stroke and Serum MMP-2 and MMP-9 Expressions
BT  - Proceedings of the 3rd International Conference on Advances in Energy and Environmental Science 2015
PB  - Atlantis Press
SP  - 890
EP  - 893
SN  - 2352-5401
UR  - https://doi.org/10.2991/icaees-15.2015.164
DO  - 10.2991/icaees-15.2015.164
ID  - Jiang2015/07
ER  -