Activity of Sambiloto Extract (Andrographis paniculata Ness) in Reducing Total Blood Cholesterol Levels Hypercholesterolemia Rats
- 10.2991/icase-18.2018.33How to use a DOI?
- blood cholesterol level, hypercholesterolemia , Sambiloto extract
Cholesterol is one of the causes of coronary heart disease. The research objective is Assessing dosege of Sambiloto extract in reducing blood cholesterol levels rats (Rattus norvegicus) hypercholesterolemia. The research method is experimental, using Completely Randomized Design (CRD) 3 replications, 6 treatments are: 1) D0 = normal control; 2) D1 = positive control of cholesterol; 3) D2 = comparator simvastatin 2mg/200 g body weight; 4) D3 = dose of 100 mg sambiloto/200 g body weight; 5) D4 = dose 200 mg sambiloto / 200 g body weight; 6) D5 = dose of 400 mg sambiloto/200 g body weight. Rats that have been tested are white male Wistar rats aged 2 months, weight ± 200 g. Analysis using Anova, and further test using DMRT, α 5%. The results of the experiment showed that sambiloto extract of 100 mg/200 g body weight, 200 mg/200 g body weight; 400 mg/200 g body weight and a simvastatin comparator 2 mg/200 g body weight all of that can reduce the total cholesterol level of rats blood that be made hypercholesterolemia. Interestingly, the dose of 400 mg/200 g body weight has the same ability as simvastatin dose of 2 mg/200 g body weight in reducing total blood cholesterol levels of rats by 51%, considering the risk of hypocholesterolemia.
- © 2018, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Ms. Sudarmi AU - Wiwik Darmini AU - Ms. Wartini PY - 2018/10 DA - 2018/10 TI - Activity of Sambiloto Extract (Andrographis paniculata Ness) in Reducing Total Blood Cholesterol Levels Hypercholesterolemia Rats BT - Proceedings of the International Conference on Applied Science and Engineering (ICASE 2018) PB - Atlantis Press SP - 120 EP - 122 SN - 2352-5401 UR - https://doi.org/10.2991/icase-18.2018.33 DO - 10.2991/icase-18.2018.33 ID - Sudarmi2018/10 ER -