Proceedings of the 7th International Conference on Biological Science (ICBS 2021)

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Hematology Profile of Female Guinea Pig (Cavia porcellus (Linnaeus, 1758)) with Diet Variations

Authors
Naila Nabila Rahmani1, Ayu Aziza Ar Rachid1, Laksmindra Fitria2, *
1Student of Undergraduate Program in Faculty of Biology, Universitas Gadjah Mada, Yogyakarta. Jalan Teknika Selatan, Caturtunggal, Depok, Sleman, D.I. Yogyakarta 55284, Indonesia
2Laboratory of Animal Physiology, Faculty of Biology, Universitas Gadjah Mada, Yogyakarta. Jalan Teknika Selatan, Caturtunggal, Depok, Sleman, D.I. Yogyakarta 55284, Indonesia
*Corresponding author. Email: laksmindraf@ugm.ac.id
Corresponding Author
Laksmindra Fitria
Available Online 2 May 2022.
DOI
10.2991/absr.k.220406.005How to use a DOI?
Keywords
Cavia porcellus; Diet type; Guinea pigs; Hematology; Laboratory animal
Abstract

Guinea pigs (Cavia porcellus (Linnaeus, 1758)) is a rodent other than rats and mice that are commonly used in biomedical research because of its physiological similarity to humans. To meet the requirement as a standard laboratory animal, the care management of GP needs to be controlled, one of which is by diet. The standard diet for GP is still limited in Indonesia, therefore GP is fed with a rabbit diet. According to references, inappropriate diet affects hematology profile. This research will be carried out to compare hematology profiles in GP fed with standard and nonstandard diets. Nine female GP were assigned into three groups, given a variety of diets based on the research design: Group BV (NS-NS-S), BVL (NS-S-S), and BL (S-S-S). The research lasted for 84 days, and blood was collected every 28 days. Hematology data profiled using fully automatic hematology analyzer Sysmex XP-100 with the following parameters: RBC, HGB, HCT, MCV, MCH, MCHC, WBC, %LYM, %NEU, %MXD, #LYM, #NEU, #MXD, N/L, PLT, PDW, MPV, P-LCR dan PCT. Cell morphology was observed through smear slide, stained by Giemsa 3%. There were significant (p<0,05) decrease in RBC, HGB, HCT, and MCHC. There were also significant (p<0,05) increases in MCV value, WBC, NEUT#, PLT, and PCT. The significant changes especially happen in the BL group. Based on the result, it can be concluded that the diet alteration to the standard diet changes the value of RBC, HGB, HCT, MCV, MCHC, WBC, NEUT#, PLT, MPV, and PCT. However, the change was ranging in the normal value, so the nonstandard diet was still safe to be given with vegetable supplementary every day.

Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

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Volume Title
Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
Series
Advances in Biological Sciences Research
Publication Date
2 May 2022
ISBN
978-94-6239-573-2
ISSN
2468-5747
DOI
10.2991/absr.k.220406.005How to use a DOI?
Copyright
© 2022 The Authors. Published by Atlantis Press International B.V.
Open Access
This is an open access article distributed under the CC BY-NC 4.0 license.

Cite this article

risenwbib
TY  - CONF
AU  - Naila Nabila Rahmani
AU  - Ayu Aziza Ar Rachid
AU  - Laksmindra Fitria
PY  - 2022
DA  - 2022/05/02
TI  - Hematology Profile of Female Guinea Pig (Cavia porcellus (Linnaeus, 1758)) with Diet Variations
BT  - Proceedings of the 7th International Conference on Biological Science (ICBS 2021)
PB  - Atlantis Press
SP  - 26
EP  - 38
SN  - 2468-5747
UR  - https://doi.org/10.2991/absr.k.220406.005
DO  - 10.2991/absr.k.220406.005
ID  - Rahmani2022
ER  -