Potential of Purple Corn Anthocyanin Extract as A Hypolipidemic Agent: An In-Silico Analysis

DOI

10.2991/978-94-6463-048-0_20How to use a DOI?

Keywords

Purple Corn Anthocyanin Extract; Hypolipidemic Agent; Mechanism Of Action; In-Silico Study

Abstract

Hyperlipidemia remains an important risk factor for cardiovascular diseases, including myocardial infarction and stroke. Some standard hypolipidemic drugs available in the market still do not meet expectations in lowering lipid levels. Investigation of alternative hypolipidemic agents continues to be carried out, including using purple corn plants with high-anthocyanin content. Plant anthocyanins have been shown to play an important role in lowering blood lipid levels. Here, we explored the potential of anthocyanin compounds in purple corn as a lipid-lowering agent through various mechanisms of action using an in-silico analysis. A total of fourteen proteins known to play a role in modulating blood lipid levels were set as target in molecular docking. Three active compounds from purple corn anthocyanin extract namely cyanidin-3-glucoside, cyanidin chloride, and peonidin-3-glucoside were used as ligands. The docking methods used the Protein-Ligand ANT System (PLANTS) to determine the binding affinities of those ligands to all target proteins and visualization of docking results displayed using Discovery Studio. Molecular docking of the three ligands with target proteins showed that purple corn anthocyanin extracts bound effectively to the active site of AMPK (adenosine monophosphate-activated protein kinase), ATP (adenosine triphosphate) citrate lyase, FABP4 (fatty acid-binding protein), glucokinase, and proprotein convertase subtilisin/kexin type 9 (PCSK9). Testing ligands c3g and p3g showed a better potency than cya-ch in lowering lipid serum level. In-silico analysis showed that purple corn anthocyanin extract has potential as a hypolipidemic agent, and it should be confirmed by a wet lab setup.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Isnatin Miladiyah
AU  - Satyo Nuryadi
PY  - 2022
DA  - 2022/12/19
TI  - Potential of Purple Corn Anthocyanin Extract as A Hypolipidemic Agent: An In-Silico Analysis
BT  - Proceedings of the 3rd International Conference on Cardiovascular Diseases (ICCvD 2021)
PB  - Atlantis Press
SP  - 173
EP  - 182
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-048-0_20
DO  - 10.2991/978-94-6463-048-0_20
ID  - Miladiyah2022
ER  -