Effect of schizandra B on reorganization of primary hippocampus neurons dendritic spine induced by epilepsy
- https://doi.org/10.2991/iceesd-18.2018.80How to use a DOI?
- schizandra B; dendritic spine; glutamate
To investigate the effect of schizandra B(Sch B) on reorganization of primary hippocampus cells dendritic spines induced by Glu. Methods: The primary hippocampus cells were divided into control group, model group and Sch B group. The primary cells in control group were untreated; the primary cells in model group were treated with Glu(15mmol.L-1)for 24h. The primary cells in Sch B group were firstly pretreated with Sch B（0.5μmmol.L-1）for 2h, and exposed to Glu(15mmol.L-1)for 24h. Results: A significant decrease of spines in number was found in the model group cells（3± 2.0/ 10μm n=12） when compared whose those in the control（12± 3.0/μm n=10，p<0.01,t-test）. A slightly decrease of spines in number were found in cells of Sch B group (8± 2.0/ 10μm n=12). Western blot analysis revealed that there is no effect on the total levels of actin and cofilin; However, it can decrease the levels of p-cofilin in the model group. The levels of p-cofilin in Sch B Group is higher than those in model group. Conclusion: Sch B can protect the damage of dendritic spines caused by Glu that is related to inhibit the activation of p-cofilin.
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Cite this article
TY - CONF AU - Yan Song AU - Chunmei Wang AU - Jianguang Chen PY - 2018/05 DA - 2018/05 TI - Effect of schizandra B on reorganization of primary hippocampus neurons dendritic spine induced by epilepsy BT - Proceedings of the 2018 7th International Conference on Energy, Environment and Sustainable Development (ICEESD 2018) PB - Atlantis Press SP - 450 EP - 453 SN - 2352-5401 UR - https://doi.org/10.2991/iceesd-18.2018.80 DO - https://doi.org/10.2991/iceesd-18.2018.80 ID - Song2018/05 ER -