Proceedings of the 2018 7th International Conference on Energy, Environment and Sustainable Development (ICEESD 2018)

Effect of schizandra B on reorganization of primary hippocampus neurons dendritic spine induced by epilepsy

Authors
Yan Song, Chunmei Wang, Jianguang Chen
Corresponding Author
Yan Song
Available Online May 2018.
DOI
https://doi.org/10.2991/iceesd-18.2018.80How to use a DOI?
Keywords
schizandra B; dendritic spine; glutamate
Abstract

To investigate the effect of schizandra B(Sch B) on reorganization of primary hippocampus cells dendritic spines induced by Glu. Methods: The primary hippocampus cells were divided into control group, model group and Sch B group. The primary cells in control group were untreated; the primary cells in model group were treated with Glu(15mmol.L-1)for 24h. The primary cells in Sch B group were firstly pretreated with Sch B(0.5μmmol.L-1)for 2h, and exposed to Glu(15mmol.L-1)for 24h. Results: A significant decrease of spines in number was found in the model group cells(3± 2.0/ 10μm n=12) when compared whose those in the control(12± 3.0/μm n=10,p<0.01,t-test). A slightly decrease of spines in number were found in cells of Sch B group (8± 2.0/ 10μm n=12). Western blot analysis revealed that there is no effect on the total levels of actin and cofilin; However, it can decrease the levels of p-cofilin in the model group. The levels of p-cofilin in Sch B Group is higher than those in model group. Conclusion: Sch B can protect the damage of dendritic spines caused by Glu that is related to inhibit the activation of p-cofilin.

Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 2018 7th International Conference on Energy, Environment and Sustainable Development (ICEESD 2018)
Series
Advances in Engineering Research
Publication Date
May 2018
ISBN
978-94-6252-503-0
ISSN
2352-5401
DOI
https://doi.org/10.2991/iceesd-18.2018.80How to use a DOI?
Copyright
© 2018, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Yan Song
AU  - Chunmei Wang
AU  - Jianguang Chen
PY  - 2018/05
DA  - 2018/05
TI  - Effect of schizandra B on reorganization of primary hippocampus neurons dendritic spine induced by epilepsy
BT  - Proceedings of the 2018 7th International Conference on Energy, Environment and Sustainable Development (ICEESD 2018)
PB  - Atlantis Press
SP  - 450
EP  - 453
SN  - 2352-5401
UR  - https://doi.org/10.2991/iceesd-18.2018.80
DO  - https://doi.org/10.2991/iceesd-18.2018.80
ID  - Song2018/05
ER  -