Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)

Effectiveness of CoronaVac Vaccine in Health Workers in Indonesia: A Case-Control Study

Authors
Delima Delima1, *, Nurhayati Nurhayati1, Sri Idaiani1, Harimat Hendarwan1, Lucie Widowati1, Ingan Ukur Tarigan1, Nurfi Afriansyah1, Sundari Wirasmi1, Diah Yunitawati1, Setyo Adiningsih1, Hadjar Siswantoro2, Tince A. Jovina2, Yenni Risniati2, Rossa Avrina2, Armaji K. Syarif2, Nita Prihartini2, Narendro Arifia2, Yusi D. Nurcahyani2, Evi I. Natalia2, Made D. Susilawati2, Devi Anisiska3, Mawari Edy4, Timor Utama4
1Research Organization for Health, National Research and Innovation Agency, Jakarta Pusat, Indonesia
2Health Policy Agency, Ministry of Health, Jakarta Pusat, Indonesia
3Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta Pusat, Indonesia
4Human Resources for Health Development and Empowerment Agency, Ministry of Health, Jakarta Pusat, Indonesia
*Corresponding author. Email: delima@brin.go.id
Corresponding Author
Delima Delima
Available Online 1 March 2023.
DOI
10.2991/978-94-6463-112-8_70How to use a DOI?
Keywords
case-control; effectiveness; CoronaVac; COVID-19; health worker
Abstract

Despite various platforms, vaccines are expected to be an essential effort to control COVID-19. Phase 3 clinical trials for CoronaVac, one of the inactivated virus vaccines, in Indonesia showed a promising efficacy of 65.3%. This study aimed to assess CoronaVac effectiveness in health workers against symptomatic COVID-19 and its severity after the vaccination program started on 13 January 2021. It was a case-control study with a ratio of 1 case: 4 controls. Data collection was conducted from August to October 2021 in several hospitals and primary health centers in 14 cities/regencies of Indonesia. Cases were health workers with symptomatic COVID-19, confirmed by RT-PCR or antigen rapid test in the period of 13 January 2021 to the data collecting time. Controls were health workers never been diagnosed with COVID-19. Hospitalized subjects’ data were extracted from medical records and input by an enumerator into LimeSurvey, an online survey tool. Non-hospitalized subjects and non-COVID-19 subjects filled the questionnaire by themselves in LimeSurvey. A total of 913 cases and 3342 controls met the criteria. CoronaVac effectiveness was analyzed and adjusted for gender, age, and comorbidity. Fully vaccinated gave 92.1% (95% CI 90.0—93.8; p = 0.0001) effectiveness in preventing symptomatic COVID-19; 96.4% (95% CI 95.3—97.3; p = 0.0001) for moderate/severe cases and 70.3% (95% CI 56.9—79.6; p = 0.0001) for mild cases. Partially vaccinated only gave 27.5% (95% CI 0.11—47.4; p = 0.049) effectiveness in preventing symptomatic COVID-19 incidence. It concludes that 2 doses of CoronaVac are effective to prevent symptomatic and moderate to severe cases in health workers.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
Series
Advances in Health Sciences Research
Publication Date
1 March 2023
ISBN
978-94-6463-112-8
ISSN
2468-5739
DOI
10.2991/978-94-6463-112-8_70How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

TY  - CONF
AU  - Delima Delima
AU  - Nurhayati Nurhayati
AU  - Sri Idaiani
AU  - Harimat Hendarwan
AU  - Lucie Widowati
AU  - Ingan Ukur Tarigan
AU  - Nurfi Afriansyah
AU  - Sundari Wirasmi
AU  - Diah Yunitawati
AU  - Setyo Adiningsih
AU  - Hadjar Siswantoro
AU  - Tince A. Jovina
AU  - Yenni Risniati
AU  - Rossa Avrina
AU  - Armaji K. Syarif
AU  - Nita Prihartini
AU  - Narendro Arifia
AU  - Yusi D. Nurcahyani
AU  - Evi I. Natalia
AU  - Made D. Susilawati
AU  - Devi Anisiska
AU  - Mawari Edy
AU  - Timor Utama
PY  - 2023
DA  - 2023/03/01
TI  - Effectiveness of CoronaVac Vaccine in Health Workers in Indonesia: A Case-Control Study
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 774
EP  - 784
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_70
DO  - 10.2991/978-94-6463-112-8_70
ID  - Delima2023
ER  -