Effectiveness of CoronaVac Vaccine in Health Workers in Indonesia: A Case-Control Study

Delima Delima; Nurhayati Nurhayati; Sri Idaiani; Harimat Hendarwan; Lucie Widowati; Ingan Ukur Tarigan; Nurfi Afriansyah; Sundari Wirasmi; Diah Yunitawati; Setyo Adiningsih; Hadjar Siswantoro; Tince A. Jovina; Yenni Risniati; Rossa Avrina; Armaji K. Syarif; Nita Prihartini; Narendro Arifia; Yusi D. Nurcahyani; Evi I. Natalia; Made D. Susilawati; Devi Anisiska; Mawari Edy; Timor Utama

doi:10.2991/978-94-6463-112-8_70

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Effectiveness of CoronaVac Vaccine in Health Workers in Indonesia: A Case-Control Study

Authors

Delima Delima¹^{, *}, Nurhayati Nurhayati¹, Sri Idaiani¹, Harimat Hendarwan¹, Lucie Widowati¹, Ingan Ukur Tarigan¹, Nurfi Afriansyah¹, Sundari Wirasmi¹, Diah Yunitawati¹, Setyo Adiningsih¹, Hadjar Siswantoro², Tince A. Jovina², Yenni Risniati², Rossa Avrina², Armaji K. Syarif², Nita Prihartini², Narendro Arifia², Yusi D. Nurcahyani², Evi I. Natalia², Made D. Susilawati², Devi Anisiska³, Mawari Edy⁴, Timor Utama⁴

¹Research Organization for Health, National Research and Innovation Agency, Jakarta Pusat, Indonesia

²Health Policy Agency, Ministry of Health, Jakarta Pusat, Indonesia

³Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta Pusat, Indonesia

⁴Human Resources for Health Development and Empowerment Agency, Ministry of Health, Jakarta Pusat, Indonesia

^*Corresponding author. Email: delima@brin.go.id

Corresponding Author

Delima Delima

Available Online 1 March 2023.

DOI: 10.2991/978-94-6463-112-8_70 How to use a DOI?
Keywords: case-control; effectiveness; CoronaVac; COVID-19; health worker
Abstract: Despite various platforms, vaccines are expected to be an essential effort to control COVID-19. Phase 3 clinical trials for CoronaVac, one of the inactivated virus vaccines, in Indonesia showed a promising efficacy of 65.3%. This study aimed to assess CoronaVac effectiveness in health workers against symptomatic COVID-19 and its severity after the vaccination program started on 13 January 2021. It was a case-control study with a ratio of 1 case: 4 controls. Data collection was conducted from August to October 2021 in several hospitals and primary health centers in 14 cities/regencies of Indonesia. Cases were health workers with symptomatic COVID-19, confirmed by RT-PCR or antigen rapid test in the period of 13 January 2021 to the data collecting time. Controls were health workers never been diagnosed with COVID-19. Hospitalized subjects’ data were extracted from medical records and input by an enumerator into LimeSurvey, an online survey tool. Non-hospitalized subjects and non-COVID-19 subjects filled the questionnaire by themselves in LimeSurvey. A total of 913 cases and 3342 controls met the criteria. CoronaVac effectiveness was analyzed and adjusted for gender, age, and comorbidity. Fully vaccinated gave 92.1% (95% CI 90.0—93.8; p = 0.0001) effectiveness in preventing symptomatic COVID-19; 96.4% (95% CI 95.3—97.3; p = 0.0001) for moderate/severe cases and 70.3% (95% CI 56.9—79.6; p = 0.0001) for mild cases. Partially vaccinated only gave 27.5% (95% CI 0.11—47.4; p = 0.049) effectiveness in preventing symptomatic COVID-19 incidence. It concludes that 2 doses of CoronaVac are effective to prevent symptomatic and moderate to severe cases in health workers.
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
Series: Advances in Health Sciences Research
Publication Date: 1 March 2023
ISBN: 10.2991/978-94-6463-112-8_70
ISSN: 2468-5739
DOI: 10.2991/978-94-6463-112-8_70 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

ris enw bib

TY  - CONF
AU  - Delima Delima
AU  - Nurhayati Nurhayati
AU  - Sri Idaiani
AU  - Harimat Hendarwan
AU  - Lucie Widowati
AU  - Ingan Ukur Tarigan
AU  - Nurfi Afriansyah
AU  - Sundari Wirasmi
AU  - Diah Yunitawati
AU  - Setyo Adiningsih
AU  - Hadjar Siswantoro
AU  - Tince A. Jovina
AU  - Yenni Risniati
AU  - Rossa Avrina
AU  - Armaji K. Syarif
AU  - Nita Prihartini
AU  - Narendro Arifia
AU  - Yusi D. Nurcahyani
AU  - Evi I. Natalia
AU  - Made D. Susilawati
AU  - Devi Anisiska
AU  - Mawari Edy
AU  - Timor Utama
PY  - 2023
DA  - 2023/03/01
TI  - Effectiveness of CoronaVac Vaccine in Health Workers in Indonesia: A Case-Control Study
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 774
EP  - 784
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_70
DO  - 10.2991/978-94-6463-112-8_70
ID  - Delima2023
ER  -

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