Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
Ika Nurlaila, Novaria S. D. Panjaitan, Rosantia Sarassari, Rika Rachmalina, Hayani Anastasia, Yunefit Ulfa, Gurendro Putro, Sela S. Mariya, Anna L. Poetranto, Rozana I. Agustiya
Combination of Antibacterial Activity of Ethanol Extract of Meniran Leaves and Kenikir Leaves Against Shigella dysenteriae
Rizal M. Rukmana, Antoni A. D. Sawal, Dionysius A. A. Wibawa
Shigellosis is an acute inflammatory disease in the human digestive tract. One of the pathogenic bacteria that causes shigellosis is Shigella dysenteriae. Some natural ingredients believed to have good antibacterial activities are Meniran (Phyllanthus niruri L.) and Kenikir (Cosmos caudatus Kunth.)....
Antifungal Activity of Peptide Fractions from Goat, Mare and Soybean Milk to Candida albicans and Trichophyton mentagrophytes
Eni Kusumaningtyas, Ermayati Ermayati, Suherman Suherman, Dwi Endrawati, Riza Z. Ahmad
Candida albicans and Trichophyton mentagrophytes are pathogenic fungi that could induce disease in animal and human. Limited non-toxic antifungal and the presence of resistance are triggering the search for novel alternative. Antifungal peptides gain more interest since their native protein are very...
Antimicrobial Resistance of Escherichia Coli Isolated from Cecum and Carcasses Samples of Broiler Chickens
Susan M. Noor, Suhaemi Suhaemi, Sumirah Sumirah, S. Mulyati, T. Ariyanti, F. Rachmawati, Andriani Andriani
Poultry production is an important part of the agricultural industry in many countries, including Indonesia. Antimicrobial agents are widely used in the poultry industry to reduce the significant losses caused by Escherichia coli infections and welfare of animals. However, utilizing antibiotics in food...
Antibacterial Properties of Bacteria Associated with a Marine Sponge from Thousand Islands, Indonesia
Tutik Murniasih, Joko T. Wibowo, Masteria Y. Putra, Febriana Untari, Rosinta Handinata
Marine invertebrates, especially sponges, have been recognized as the source of marine natural products with various bioactivities. The problematic sustainability of the natural product research from sponges drives the research change from the sponge to the associated microbes. In the attempt to find...
Immunocytochemistry Studies Using Microtubule-Associated Protein-2 (MAP-2) Markers on Neural Differentiation of Mesenchymal Stem Cells from Rat Bone Marrow
Ariyani Noviantari, Radiana D. Antarianto, Lutfah Rif’ati, Ratih Rinendyaputri, Uly A. Nikmah, Lisa A. Lienggonegoro, Masagus Zainuri, Frans Dany
Mesenchymal stem cells (MSCs) can differentiate into neurons, which can be used in cell therapy. Endogenous genes and neurotrophic factors such as nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), and neurotrophin-3 regulate neural stem cell proliferation and differentiation (NT-3)....
Analysis of Sea Cucumber Metabolites as Phytate Inhibitor in Human ZiP Transporter: Molecular Docking Study
Gita Syahputra, Nunik Gustini, Melva Louisa, Fadilah Fadilah, Masteria Y. Putra
One of the causes of zinc deficiency is decreased zinc intake or impaired absorption of zinc which causes zinc bioavailability to decrease in the blood. Phytate is one of the compounds found in food that can interfere with zinc absorption in the human digestive system. The formation of a zinc complex...
9-POHSA Reduces LPS-Stimulated TNF-α Expression in Rat Hepatocyte: The Involvement of NF-KB-p65 Subunit
Jiro H. Situmorang, Ching-Hui Loh, Chih -Yang Huang
Metabolic (dysfunction) associated fatty liver disease (MAFLD) is phenotypically displayed by a buildup of fat in the liver. Over time, a patient with MAFLD tends to develop the disease into worse states like liver fibrosis and cirrhosis. The transition from simple steatosis into steatohepatitis is marked...
Administration of Lactobacillus acidophilus FNCC 0051 in Rattus norvegicus with Type-1 Diabetes Mellitus: Glucose and Lipid Metabolism
Mardhatillah Sariyanti, Sylvia R. Putri, Tika P. Sari, Ory L. Fitkarani, Besly Sinuhaji, Nikki A. Massardi, Novriantika Lestari, Elvira Yunita, Diah A. A. Dita
The imbalance of gut microbiota contributes in development of type 1 diabetes melitus (DM), which is a chronic autoimmune disease characterized by immune-mediated destruction of the insulin-producing pancreatic beta (ß) cells. Around 7–12% of all diabetics were type 1 DM with the most cases occurred...
Decellularization Techniques to Manufacture Ovary Cancer Niche Scaffold as Prototype for 3D Cancer Cell Culture
Siti M. G. Maya, Nurhamitha Humairoh, Muhammad Suhaeri, Farah Nurlidar, Septelia I. Wanandi, Tricia D. Anggraeni, Radiana D. Antarianto
Ovarian cancer contains a microenvironment that supports the proliferation of cancer cells. The microenvironment of ovarian cancer can be produced in vitro by the manufacture of an ovarian cancer scaffold. The scaffold provides conditions structurally similar to the in vivo microenvironment for communication...
Frans Dany, Fifi Retiaty
Reactive hypoglycaemia (RH) is a condition when post-prandial plasma glucose level drops, usually <70 mg/dl. Its exact cause is unknown and associated with risk of diabetes among non-diabetic individuals. Attempts are made to predict RH but met with difficulties due to varied data characteristics...
Liftia L. Syifa, Awal Prasetyo, Udadi Sadhana, Agus Subagio, Susilo A. Widyanto, Arlita L. Antari, Stefan Arman, Anthony S. Hambali, Soerjanto Tjahjono, Saras Pujowati, Ai D. Nuraeni, Muflihatul Muniroh, Neni Susilaningsih
The inhalant increasing risk of transmission in public transportation, is buses. Biosmart and safe bus apply the principle that the bus compartment which is a biological environment must be in a balanced state according to the disease triangle concept that is influenced by the host, in this case is the...
High Glucose Inhibits the Expression of EtcABC Which Resulted in Negative Regulation of Type III Fimbriae in Klebsiella pneumoniae Isolates
Novaria S. D. Panjaitan, Soo Po-Chi, Lin Yin-Jia, Tsai Yi-Jhen
Klebsiella pneumoniae is one of abundant normal flora in human, but also well-studied as an opportunistic pathogen due to its ability to form biofilm. Biofilm could be formed by biofilm-forming bacteria as its survival method. Valid example for biofilm-associated medical issue is catheter-related diseases,...
Peni Ahmadi, Takahiro Haruyama, Nobuyuki Kobayashi, Junichi Tanaka
Dengue is a viral infection spread by mosquitos that occur in tropical and subtropical areas in the world. Presently, there is no directly acting drug against Dengue Virus (DeNV) for clinical use. Therefore, developing new medicines is required to control the severity of outbreaks. In this proceeding,...
Sabar Pambudi, Tika Widayanti, Febby N. Ningsih, Asri Sulfianti, Jodi Suryanggono, Ika Nurlaila
One of the abundant biomarkers in tuberculosis (TB) infected human serum is the Ag85B antigen. The quest for protein biomarkers has been conducted to develop a diagnostic kit and vaccine for TB. Numerous studies have demonstrated that the development of monoclonal antibodies (mAbs) that recognize a specific...
Tenofovir Lamivudine Efavirenz Side Effect and Its Efficacy Among People Living with HIV in Jayapura
Setyo Adiningsih, Mirna Widiyanti, Muhammad F. Rokhmad
Tenofovir lamivudine efavirenz (TLE) as a single-tablet regimen is preferred to the long use of combination antiretroviral therapy. TLE is safer than another antiretroviral drug regimen for first-line of Human immunodeficiency virus (HIV) treatment. However, there is little information about the side...
Genetic Stability Test of Pichia pastoris Carrying Integrated Pre-membrane Envelope Gene of DENV3 Indonesian Strain
Asri Sulfianti, Angelina Gill, Astutiati Nurhasanah, Tika Widayanti, Sabar Pambudi
In recent years, the methylotrophic Pichia pastoris has become an increasingly famous host for recombinant protein expressions. As a eukaryote, this yeast offers several advantages, including simplicity of genetic manipulation, stable expression, and low-cost scalable fermentation techniques. Previous...
Effect of Tween 20 Inclusion in Oligopeptide-Based Liposome Formulation on Transfection Agent/DNA Particle Size, Complex Stability and Gene Expression
Tarwadi Tarwadi, Damai R. Setyawati, Sabar Pambudi, Prasetyawan Yunianto, Rahmana E. Kartasasmita, Heni Rachmawati, Sukmadjaja Asyarie
The main requirement of a transfection agent has to condense DNA efficiently, protect the DNA from nucleases and other degrading enzymes during its transport in a target cell. In this research, Polysorbate 20 which is commercially known as Tween 20 has been supplemented to oligopeptide-based liposome...
G6PD Deficiency and Its Correlation to Anaemia Among People Living in High Endemic Malaria Area, Nimbokrang, Papua, Indonesia
Muhammad F. Rokhmad, Yustinus Maladan, Setyo Adiningsih, Mirna Widiyanti, Ivon Ayomi
G6PD deficiency is an X-linked enzymopathy and is the most prevalent genetic disorder in the world, affecting 500 million people, and it frequently causes hemolytic anemia. This genetic disorder is often associated with malaria because of its high prevalence in malaria endemic areas such as Africa, Southeast...
Hasta H. Idrus, Sunarno Sunarno, Ratih Rinendyaputri, Syamsu Rijal, Yusriani Mangarengi, Masriadi Masriadi, Rasfayanah Rasfayanah, Hermiaty Nasruddin
Typhoid fever is one of the common diseases in developing countries. This is attributable to Salmonella typhi bacteria. The water from the unripe Manila sapodilla was often to be given as a drink on typhoid fever patients. Indonesia is a country that is rich in natural ingredients that can be used as...
The Effect of Indonesian Royal Jelly Supplementation on the Growth of Hybridoma and Its Monoclonal Antibody Production
Febby N. Ningsih, Tika Widayanti, Muhamad Sahlan, Andri P. Pramono, Sabar Pambudi
Monoclonal antibody (mAb) is the material that is used widely for biological experiments, therapeutic, and diagnosis. The production of monoclonal antibodies by in vitro method is still challenging, and it takes a high cost due to the use of animal-derived serum as the main growth-promoting factor. The...
The Prevalence of Combined Three Markers of Hepatitis B in Indonesia: Further Analysis of National Basic Health Research, 2013
Sarwo Handayani, Frans Dany
Hepatitis B is still a health problem in the world and Indonesia. A combination of three markers, HBsAg, anti-HBc, and anti-HBs, provides further information on the hepatitis B active infection and immunity status. Therefore, the objective of this study is to identify the prevalence of combined three...
Reza Y. Purwoko, Syahrul Tuba, Sri Idaiani, Harimat Hendarwan, Islamudin Ahmad, Harryadin Mahardika, Kevin Tandarto, Caroline Oktarina, Reganedgary Jonlean
One of the plants that has been used for generations in Borneo is kratom or Mitragyna speciosa. The leaves are used as analgesics and antidepressants. The plant is grown for export to countries other than Indonesia where consumption of this plant as a beverage is still legal, generally in tea from leaves...
In Silico Approach: Docking Study of Compounds in Ardisia Plant as COX-2 Inhibitor and Its Comparison with Existing Therapeutic Drugs
Maya D. Rahayu, Nurhadi Nurhadi, Galih K. Aji, Devi Permatasari, Susi Kusumaningrum
Inflammation, a defense mechanism, happens during infections and injuries, involving complex immune responses. Medication using non-steroidal anti-inflammatory (NSAID) as Cyclooxygenase-2 (COX-2) inhibitors is clinically effective. It, however, has cardiovascular side effects. Thus, screening of COX-2...
Antioxidant Activity of Ethanolic Extract of Peel and Seed Melinjo (Gnetum gnemon) Based on Color Variations
Martha Sari, Siti I. Rahmawati, Fauzia N. Izzati, Bustanussalam, Masteria Y. Putra
Melinjo (Gnetum gnemon Linn) is a plant of the genus Gnetacea that has been identified as having various biological activities, including antioxidants. This study aimed to analyze the biological activity of Gnetum gnemon for the determination of total phenolics, anti-free radicals (antioxidants), and...
Predicting the Potency of Bioactive Compounds in Murraya paniculata as an Antiaging Agent: Collagenase Inhibition by Molecular Docking and Antioxidant Activity Assessment
Olivia B. Pongtuluran, Idah Rosidah, Siska A. Kusumastuti, Nuralih Nuralih, Damai Ria
Depleting collagen in the skin due to the appearance of the collagenase enzyme is one of the causes of aging. The objective of this study was to predict the effectiveness of some bioactive compounds found in the leaves of Murraya paniculata, known as Kemuning in Indonesia, by molecular docking as a potential...
Rizna T. Dewi, Sukirno Sukirno, Rifqah Azzahra
Morinda citrifolia L. (Mengkudu) has been widely used in herbal medicine to prevent and treat various diseases. In the Indonesian Original Herbal Medicine Formularies list, Mengkudu is an ingredient for treating hypertension and dyslipidemia. The various efficacy activities are due to the great active...
Sri Handayani, Dwi Ni’maturrohmah, Anastasia W. Indrianingsih, Khoirun Nisa, Anjar Windarsih, Cici Darsih, Ardiba R. Sefrienda, Ade E. Suryani, Sari Haryanti
Aloe vera is a beneficial plant used for food supplements, cosmetics, and medicine for years. Currently, the popularity of herbal, cosmetic, foods, and beverages products containing aloe gel induce a big demand in the global market for aloe vera. Aloesin and its derivatives are chromone compounds found...
Vera Permatasari, Muhammad Eka Prastya, Tjandrawati Mozef, Gian Primahana, Wawan Sujarwo, Sri Rahayu
Meliaceae plant is a large, evergreen plant which extracts are rich in natural promising compounds with numerous bioactivities including antioxidant, antimicrobial and cytotoxic properties. The aim of the present work was to evaluate the antioxidant activity of phenolic and flavonoid which were investigated...
Eris Septiana, Siti I. Rahmawati, Fauzia N. Izzati, Peni Ahmadi, Diah A. Wulandari, Bustanussalam Bustanussalam, Mega F. Warsito, Masteria Y. Putra
Celery is a medicinal plant that is widely used as an ingredient in traditional medicine in Indonesia. Scientifically, celery extract has the ability as an antioxidant, antibacterial, anti-breast cancer, and inhibiting ACE enzyme activity as antihypertensive. The use of maceration and ultrasound-assisted...
Antioxidant and Antibacterial Properties Derived from Horsfieldia Spicata (Roxb.) J. Sinclair Stem Bark Extract and Its Active Fraction
Minarti Minarti, Novita Ariani, Muhammad E. Prastya, Akhmad Darmawan, Megawati Megawati
Horsfieldia spicata (Roxb.) J. Sinclair is a species of plant from the Myristicaceae family which has more than 100 species and is widely distributed in South Asia, from India to the Philippines and Papua New Guinea. Numerous species of this family are utilized for wood, and other species are reported...
Antioxidant, Antibacterial and Antibiofilm Activities of an Endophytic Fungi, Penicillium Sp. SAF6-EGY Strain AFL.2 and Arthrinium Sp. R22-1 Strain AFL.3 Isolated from Aglaia Foveolata
Muhammad E. Prastya, Jepri A. Priyanto, Gian Primahana, Tjandrawati Mozef, Abdi W. Septama, Rizna T. Dewi, Zetryana P. Tachrim, Agustina S. Andreani, Siti I. Rahmawati, Eris Septiana
Endophytic fungi are widely underexplored in the discovery of novel bioactive compounds with promising pharmaceutical uses. Aglaia foveolata, which has important medicinal value, was investigated for its endophytic fungi to produce bioactive compounds by determining antioxidant, antibacterial, and antibiofilm...
Evaluation of Antibacterial and Antioxidant Activities of Stingless Bee (Tetragonula Laeviceps) Hive from Purwodadi Botanical Garden and LC/MS Profiles of Dichloromethane Fraction
Praptiwi Praptiwi, Ahmad Fathoni, Oscar Efendy, Dewi Wulansari, Andria Agusta
This study evaluates the potential of stingless bee (Tetragonula laeviceps) methanol extract and its fractions (hexane, dichloromethane, ethyl acetate, methanol, and acetone-water) as an antibacterial, antioxidant, phenolics content, and LC/MS profiles of dichloromethane fraction. The test was carried...
In Silico Analysis of the Inhibitory Potential of Zingiber Officinale Roscoe Compounds Against SARS-CoV-2
In traditional medicine, Z. officinale has been known and used for centuries. However, with the current ongoing COVID-19 pandemic, Z. officinale is increasingly being used to treat symptoms of COVID-19 and increase overall immunity. The presence of multiple phytochemicals contained in Z. officinale has...
Bustanussalam, Yatri Hapsari, Fauzy Rachman, Eris Septiana, Partomuan Simanjuntak
Watercress (Nasturtium officinale R.Br) is a highlands plant that has been eaten as a vegetable by many people. Watercress contains protein, calcium, phosphorus, iron, vitamin A, vitamin E, vitamin C, flavonoids and phenols. Antioxidants are components that can delay or prevent the oxidation of lipids,...
Improving the Community’s Knowledge, Attitude, and Practice on the Rational Use of Antibiotics is the Role of Primary Health Care
Selma Siahaan, Eka Purwaningsih
Antibiotic resistance (ABR) is a global health problem. It is found not only in the health sector, but the ABR issue has to be tackled cross-sectors because the root cause of ABR is multi-sectors such as agriculture, livestock, environment sectors, and community. This study aims to assess the community...
Agung D. Laksono, Ratna D. Wulandari, Ratu Matahari
Poverty could increase a mother’s chances of giving birth to a baby with a low birth weight (LBW). Low-income families have trouble supplying food for all family members, including pregnant women. Insufficient food availability at the household level is not limited to food quantity and includes food...
Behavioral Examination of Blood Pressure and Cholesterol Levels in Survivors of Non-communicable Diseases in Monitoring Health in the Early Period of the Covid 19 Pandemic: A Study in Bogor in 2021
Lely Indrawati, Dwi H. Tjandarini, Sulistyowati Tuminah, Alifa S. Putri, Woro Riyadina
The global pandemic of COVID-19 has greatly affected the lives of People Living with Non-Communicable Diseases (PLWNCDs), which in Indonesia are known as Orang yang Hidup dengan Penyakit Tidak Menular. Cardiovascular disease and other major NCDs share similar modifiable risk factors, namely lifestyle...
Lisa A. Lienggonegoro, Harimat Hendarwan, Telly Purnamasari, Nelly Puspandari, Subangkit Subangkit, Kambang Sariadji, Jontari Hutagalung, Kartika D. Puspa, Agustina Puspitasari, Sarwo Handayani, Holy A. Wibowo, Sundari N. Sofiah, Dyah A. Riana, Masri S. Maha, Vivi Setiawaty
Hospital is a place with the highest risk of Covid-19 transmission. Healthcare workers should apply safety precautions in order to avoid infection. This study was conducted to obtain information about hospital loci (rooms) that are at risk of transmission of the SARSCov-2 virus. Six hospitals located...
The Government’s Role in Promoting the Community on Children with Special Needs, Early Detection, and Handling
Hidayad H. Sholikhah, Rukmini Rukmini, Titik Sumiatin, Khoirul Rosyadi
Delays in access to assessment and intervention services for children with special needs are still a major issue. Case finding of Children with Special Needs often occurs when children enter school age. Children’s development is often far behind compared to their peers at this age. This is an important...
Ika Saptarini, Sri Idaiani, Pramita Andarwati
Midlife people tend to gain weight with age, contributing to poor health. Personality traits are often linked to health outcomes that have adverse effects. The ways of thinking, feeling, and acting summed up by broad personality traits may make people more likely to become obese. The results of previous...
Perceived Barriers Related to School Mental Health Program: A Study from Four High Schools in West Java
Indri Y. Suryaputri, Rofingatul Mubasyiroh, Bunga C. Rosha
Mental health issues frequently appear in youth and persist throughout adulthood. Interventions for adolescents’ mental health can be successfully carried out in schools. There are currently educational initiatives in place in Indonesia that emphasize mental health’s importance. Nevertheless, the actual...
Kristina L. Tobing, Alfons M. Letelay, Felly P. Senewe, Dina B. Lolong, Noer E. Pracoyo, Lilian Susanti, Oster Suriani, Aan Setiawan, Rina Marina
Tuberculosis is a significant infectious disease problem in Indonesia. According to the Indonesia Tuberculosis Prevalence Survey 2013–2014, the prevalence of TB with bacteriological confirmation was 759 per 100,000 population from 15 years old and above. The purpose of the study is to compare active...
Ownership, Usage, and Maintenance LLINs Behavior in Six Endemic Malaria Areas Post Distribution in Indonesia 2019–2020
Rina Marina, Doni Lasut, Shinta Shinta, Yusniar Ariati, Mutiara Widawati, Hariyanto Soehadi
Malaria remains a public health concern in Indonesia, especially in the east. The intervention of the Long Lasting Insecticides Nets (LLINs) distribution program is one of the strategies used to reduce malaria cases in Indonesia. Therefore, treating LLINs according to the guidelines is critical to maintaining...
Dede A. Musadad, Tri J. Angkasawati, Yusleli Usman, Rustika Rustika
Community health center (CHC) as a leading health service facility has an important role in handling public health problems, including the COVID-19 pandemic control. This study aimed to determine the readiness of CHC in the COVID-19 pandemic control. This cross-sectional study was conducted during the...
Maternal Characteristics as Predictors of the Incidence of Acute Upper Respiratory Infection in Children Under Five Years Old in Indonesia
Diah Yunitawati, Marizka Khairunnisa, Leny Latifah
The morbidity rate of acute upper respiratory infection (ARI) in children under five is still relatively high in Indonesia. Many factors are thought to influence this incident. The present study analyzed the characteristics of mothers as predictors of the incidence of acute upper respiratory infection...
Performance of Evaluation Instrument for EWARS Activities in Tanah Bumbu District and Banjar District, Indonesia
Dicky Andiarsa, Syarif Hidayat
WHO suggests all countries including Indonesia to increase early awareness and respond quickly to cases that potentially spread. Indonesia has developed a system called Early Warning Alerts and responses (EWARS) to detect any threat or an indication of an infectious disease outbreak and reported weekly...
The Optimized Fruit and Vegetable Combination for Children Aged 10–12 Years in Central Jakarta, Indonesia
Rika Rachmalina, Nur H. Utami, Hera Nurlita, Prisca P. Arfines, Tities Puspita, Sri P. H. Djaiman
Fruits and vegetables (FV) contain essential vitamins and minerals for children’s growth and development. Introduction of FV in young children can improve their preference for healthy food. The purpose of this study was to develop FV combinations based on children’s preferences and balanced diet recommendations....
Romsyah Maryam, Prima M. Widiyanti, Dalilah Dalilah
Aflatoxins are group of mycotoxins produced by Aspergillus sp., which is commonly found in agricultural products. Aflatoxins have carcinogenic, mutagenic, teratogenic and immunosuppressive properties for humans and animals. Aflatoxin B1 (AFB1) is the most toxic type of aflatoxins in nature compared to...
The Role of Community Leaders in Baduy Traditional Institutions to Increase Health Facility Deliveries
Vita Kartika, Rozana I. Agustiya
Giving birth independently without the help of a shaman or health worker is one of the traditions of the Outer Baduy Tribe that is still practiced and often results in the death of the mother and baby. To reduce the occurrence of childbirth itself, an intervention has been carried out involving community...
Nutritional Content, Food Contamination, Sensory Test on Analog Rice Based on Local Food, Arrowroot Starch (Maranata arundinaceae Linn), Corn Flour (Zea mays), Soybean Flour (Glycine Max(L) Merril)
Sri Supadmi, Ina Kusrini, Slamet Riyanto
Analog rice can be used as a substitute for rice to meet nutritional needs and as food diversification. This study was to determine the characteristics of local food-based analogs of Garut starch, Corn Flour, and Soybean Flour. The main composition of analog rice products consists of arrowroot starch...
The Relationship Between Iodine Status and Thyroid Stimulating Hormone (TSH) and Free T4 (FT4) in Women of Childbearing Age in Wonogiri Regency
Taufiq Hidayat, M. A. Musoddaq, Hadi Ashar, Sidiq Purwoko
The urinary iodine concentration (UIC) is the most common indicator for assessing the population’s iodine status. Urinary iodine does not provide information about thyroid function directly. However, iodine status is an important determinant of thyroid disorders in women of childbearing age. This study...
The Effect of Clinical Pathway Implementation on the Length of Days of Ischemic Stroke Patient Hospitalization at Three Hospitals in Indonesia
Telly Purnamasari, Rizaldy T. Pinzon, Asri C. Adisasmita, Mondastri K. Sudaryo, Trihono Trihono, Ajeng T. Endarti
Clinical pathways (CP) regarding stroke is a medical service standard necessitated ensuring quality health services at rational costs. The previous study showed that the effect of CP implication on hospitalization length has not shown conclusive results in one hospital nor considered the CP format used....
Comparison of the Variation Cost of COVID-19 Medicine Among Public and Private Hospitals in Indonesia
Wahyu P. Nugraheni, Hasbullah Thabrany
Cost information is important for efficiently allocating healthcare expenditures, estimating future budget allocation, and setting user fees to start new financing systems. Indonesia has a very high number of COVID-19 cases. Because of new instances, Indonesia requires information on the cost of COVID...
A Qualitative Study with Health Belief Model: Perceived Risks and Compliance Towards COVID-19 Prevention Measures Among Adults in Indonesia
Mara Ipa, Pandji W. Dhewantara, Jerico F. Pardosi, Heni Prasetyowati, M. E. A. Fuadiyah, Rachmalina Soerachman, Endang P. Astuti, Yuneu Yuliasih
Current policy responses in Indonesia have been focused on increasing public awareness of the risks of COVID-19. Nevertheless, there is limited information concerning public perceptions on COVID-19 pandemic that would contribute for formulating adequate preventative approaches to mitigate consequences...
Yuyun Yuniar, Rini S. Handayani, Lukman Prayitno, Andi Leny, Susyanty
Stroke is a major health problem causing 75.2% of mortality and 81.0% of disability in developing countries. It accounts for the primary causes of Indonesian deaths (15.4%). This research aims to analyze the variation of medicines costs for inpatient ischemic stroke based on the hospital, patients, and...
Evaluation of Covid-19 Vaccine Management in Indonesian Health Facilities: A Nationwide Cross-Sectional Study
Mukhlissul Faatih, Yuyun Yuniar, Nita Prihatini, Andi L. Susyanty
The Indonesian government is vaccinating all Indonesians against Covid-19. Covid-19 vaccine required a cold chain system to maintain the recommended storage and distribution temperature range. The study was conducted to describe the compliance of the vaccine management in Indonesia with Guidelines for...
The Relationship of Food Consumption Patterns to Adult Obesity Status and BMI Changes in the COVID-19 Pandemic: A Longitudinal Study
Woro Riyadina, Elisa D. Julianti, Prisca P. Arfines, Nuzuliyati Nurhidayati, Irlina R. Irawan, Mohamad Samsudin
In Indonesia, the trend of obesity continues to increase consistently, even though the government has targeted to maintain the prevalence of obesity. Obesity is a comorbidity of COVID-19. During the COVID-19 pandemic, there was a change in diet and weight gain. The purpose of this study was to determine...
Puti S. Hidayangsih, Ika Dharmayanti, Dwi H. Tjandrarini, Noor E. W. Sukoco
Climatic factors are suspected to encourage an increase in the incidence of diarrheal diseases in Indonesia, especially among children under five, as a vulnerable group and can lead to death. The problem of diarrhea for the last 3 years has almost stagnated, only slightly decreased. This study aims to...
The Effect of Central Obesity, Smoking, and Fried Food Consumption on Dyslipidemia in Adults: A Prospective Cohort Study
Sudikno Sudikno, Julianty Pradono, Sulistyowati Tuminah
Dyslipidemia is an important risk factor that can trigger the incidence of non-communicable diseases. This study aims to analyze the effect of central obesity, smoking, and consumption of fried foods on the incidence of dyslipidemia in adults aged 25–65 years. This study uses secondary data from the...
Association Between Tobacco Smoking and Gum Bleeding in Indonesian Population: Results of a National Study in 2018
Lelly Andayasari, Rofingatul Mubasyiroh, Iin Nurlinawati, Ika Saptarini, Irna Sufiawaty
Smoking is a risk factor for pathologic diseases both locally in the oral cavity and systemic diseases. Smoking tobacco has been associated with an increased risk of periodontitis. The National Basic Health Research, RISKESDAS 2018 conducted by the Ministry of Health of the Republic of Indonesia, shows...
Masdalina Pane, Sri Sulasmi, Elvieda Sariwati, Fiona Kong, Aulia Rahman
Asian Games and Asian Para Games 2018 were held consecutively in August and October 2018 in Indonesia. Unfortunately, national diphtheria outbreak in Indonesia occurs from December 2017 to February 2018. The Outbreak Response Immunization (ORI) commenced on 11 December 2017 for the affected regions....
Joko Irianto, Eva Laelasari, Athena Anwar, Kambang Sariadji
Bacteria live and grow anywhere, especially in hospitals as a place of patient care. An infected person, when coughing and touching objects, will deliver the transmission to the surrounding environment. Air is a potential means for viruses and bacteria to act as intermediaries for the transmission of...
Client’s Perceptions of Drug Abusers on the Thematic Group Activities (TGA) Innovation Program at the Rehabilitation Center of National Narcotics Agency (BNN)
Raharni Raharni, Riza Sarasvita, Siti Isfandari
The problem of narcotics in Indonesia still requires high attention and vigilance. UNODC World Drug Report reported that 269 million people worldwide abuse drugs. In Indonesia, the drug abuse prevalence rate is above 2.5%. Thematic Group Activities (TGA) is an innovation program with individual-based...
Kurnia Agustini, Idah Rosidah, Ngatinem Ngatinem, Sri Ningsih, Julham Effendi, Muhammad Amin, Bhintarti Suryohastari
Ardisia elliptica is one of Indonesian medicinal plants known as Lampeni. Some studies proved that Ardisia elliptica has activities as antibacterial, antiviral, antiplatelet, antiplasmodial and antiproliferative in cancer cell line. Its leaves contain some phytochemical compounds such as α-amyrin, β-amyrin...
The Nitric Oxide-Induced Immune Effect After Temulawak (Curcuma Xanthorrhizae Roxb.) Starch Treatment on Cyclophosphamide-Induced Rats
Tiya N. Renggani, Idah Rosidah, Shelvi Listiana, Nizar, Kurnia Agustini, Sri Ningsih
Temulawak (Curcuma xanthorrhizae RoxB.) is known as an immunostimulant medicinal herb, however its starch has not been extensively investigated. Therefore, this study aimed to assess the immunostimulant effects of temulawak starch (TS) in cyclophosphamide (CYD)-induced Sprague-Dawley male rats. Temulawak...
Study of Tablet Formulations Containing a Combination of Secang (Caesalpinia sappan L) and Gambir (Uncaria Gambir Hunter Roxb) Extracts as Uric Acid Lowering Agents
Sri Ningsih, Nisrina Firdausi, Julham Efendi, Nizar Nizar, Fahleni Fahleni
The number of people with hyperuricemia tends to increase in line with the growth in the level of community welfare. The proportional combination of secang and gambir extract (formula extract = FE) was proven to be able to reduce blood uric acid levels with an effective dose of 75 mg/kg bw (body weight)...
Convalescent Plasma Effect to Neutralization Antibody and Inflammation Parameter Level in Moderate COVID-19 Patients
Theresia M. Rahardjo, Hendra Subroto, Christian Adiutama, Mochamad Fachrureza, Anita Ramlie, Aloysius Suryawan, Diana K. Jasaputra, Jeffrey C. Mahardhika
The pandemic of COVID-19 continues with new variants. More than 401 million people in the world infected by COVID-19 and approximately 5.7 million people lost their lives. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has respiratory system as a target. This virus uses a receptor binding...
Armedy R. Hasugian
The Clinical Manifestation Journey of Covid-19 is unpredictable, even after antiviral treatment. Favipiravir is one of the promising antivirals that is expected to stop the development of the disease so that it can eliminate the clinical symptoms of Covid-19. The question is to what extent the drug Favipiravir...
Delima Delima, Nurhayati Nurhayati, Sri Idaiani, Harimat Hendarwan, Lucie Widowati, Ingan Ukur Tarigan, Nurfi Afriansyah, Sundari Wirasmi, Diah Yunitawati, Setyo Adiningsih, Hadjar Siswantoro, Tince A. Jovina, Yenni Risniati, Rossa Avrina, Armaji K. Syarif, Nita Prihartini, Narendro Arifia, Yusi D. Nurcahyani, Evi I. Natalia, Made D. Susilawati, Devi Anisiska, Mawari Edy, Timor Utama
Despite various platforms, vaccines are expected to be an essential effort to control COVID-19. Phase 3 clinical trials for CoronaVac, one of the inactivated virus vaccines, in Indonesia showed a promising efficacy of 65.3%. This study aimed to assess CoronaVac effectiveness in health workers against...
Sri Idaiani, Nurhayati Nurhayati, Delima Delima, Harimat Hendarwan, Lucie Widowati, Ingan U. Tarigan, Nurfi Afriansyah, Sundari Wirasmi, Diah Yunitawati, Setyo Adiningsih, Hadjar Siswantoro, Tince A. Jovina, Yenni Risniati, Rossa Avrina, Armaji K. Syarif, Nita Prihartini, Narendro Arifia, Yusi D. Nurcahyani, Evi I. Natalia, Made D. Susilawati, Jarir A. Thobari
It is essential to prove a vaccination program's effectiveness before initiating such a program to the entire population. Accordingly, the government of Indonesia has conducted research at the beginning of the COVID-19 vaccination program. The general objective of the current study was to assess...
Tri Yuliani, Hikmat Hikmat, Indah D. Dewijanti, Rizna T. Dewi, Marissa Angelina, Sofa Fajriah, Instiaty Instiaty
Magnesium (Mg) deficiency is found in many disease conditions ranging from infectious diseases to degenerative diseases. In COVID-19, magnesium deficiency is associated with susceptibility to infection and the development of severe infections. In this disease, magnesium has been suggested to play a role...
Dwi Endrawati, Ermayati Ermayati, Suherman Suherman, Eni Kusumaningtyas, Riza Z. Ahmad
Dermatophytosis is a fungal infection of keratinized tissue (skin, hair, and nails) caused by three genera of dermatophytes: Epidermophyton, Microsporum, and Trichophyton. Dermatophytosis is a zoonotic disease that easily spreads to other animals as well as to humans. Long treatment will give great loss...
Dudi Hardianto, Efrida Martius, Fahroziah Assyifa, Dihan Laziba, Uli J. Nasution, Fransiska C. Sekaringtyas, Juwartina I. Royani
The prevalence of Insulin Dependent Diabetes Mellitus (IDDM) has increased significantly in the last decades, resulting in an increased demand for insulin. In addition, new routes of oral and inhaled insulin require higher doses thus increasing insulin requirements. Insulin is the primary drug in patients...
Damai Ria Setyawati, Sjaikhurrizal El Muttaqien, Donny Ramadhan, Etik Mardliyati
Aluminum hydroxide (AH) is one of the aluminum-based adjuvants that forms needle-like crystalline structure with the average particle size of 1–20 µm. Due to their favorable safety profile, AH adjuvant has been used widely in various human vaccine in diphtheria, tetanus, pertussis, hepatitis, and papilloma...
Cloning and Expression of HBcAg Using Food Grade Vector pNZ8149 in Lactococcus Lactis for the Development of HBV Therapeutic Vaccine
Rifqiyah N. Umami, Rahma I. Anwar, Hidayah Murtiyaningsih, Apon Z. Mustopa
Hepatitis B virus (HBV) infection remains a major cause of chronic liver diseases which may develop into cirrhosis and hepatocellular carcinoma (HCC). Although HBV prophylactic vaccine is available, currently there is no complete cure for chronic hepatitis B (CHB). One of the alternatives for CHB treatment...
Fitrine Ekawasti, April H. Wardhana, Farlin Nepho, Eko S. Purwanto, Dyah H. Sawitri, Eny Martindah
Coccidiosis continues to be one of the most important issues in animal health and generates significant economic losses to the livestock industry in Indonesia, specifically due to Eimeria spp. Infections. Eimeria are specific to a particular host Eimeria and multi-species infections are more prevalent...
Genetic Variation of the Causal Agent of Sheep-Associated Malignant Catarrhal Fever in Buffalo in Indonesia: Using a Repeat-Sequence Polymerase Chain Reaction
Agus Wiyono, Muharam Saepulloh, Rini Damayanti
A study on the genetic variation of Ovine Herpesvirus-2 (OVH-2), the causal agent of sheep-associated malignant catarrhal fever (SA-MCF), in buffalo in Indonesia using a repeat-sequence polymerase chain reaction (RS-PCR) has been conducted. Samples of heparinized blood and/or pre-scapular or pre-femoral...
April H. Wardhana, Ening Wiedosari
The widespread occurrence of coccidiostat resistance in chicken farms has prompted the search for alternatives to treat coccidiosis caused by Eimeria tenella. This study aimed to compare the efficacy of standard artemisinin and Artemisia annua (A. annua) leaf ether extract when administered at 3–2–3...
Evaluation of Gamal Leaves (Gliricidia Sepium) as Anthelmintic Forages Against Gastrointestinal Nematodes in Sheep
Dyah H. Sawitri, April H. Wardhana, Farlin Nefho, Eko Setyo Purwanto, Eny Martindah, Wisri Puastuti
Several studies have demonstrated that ruminant-fed forages containing bioactive anthelmintics (tannins, alkaloids, and flavonoids) can be used to suppress nematode worms. The objective of this study was to examine any potential direct anthelmintic effects of G.sepium leaves containing Plant Secondary...
The Utilization of Chitosan in Streptococcus Agalactiae Encapsulation as Mastitis Vaccine Carrier Candidate
Dadang Priyoatmojo, Tri Handayani, Afi C. Trinugraha, Teguh Wahyono, Ade L. Yunus, Abdi W. Septama
Mastitis is a disease in dairy cattle that causes economic losses to farmers around the world. Mastitis is caused by microbes with Streptococcus agalactiae being the main cause of subclinical mastitis. The prevention and control of mastitis is through sanitation management, drug administration and vaccination...
The Prevalence of Soil Transmitted Helminth Among Elementary School Students in Buton, Province of South Sulawesi
R. A. Wigati, Dicky Andiarsa, Nurhidayati Nurhidayati, Tri Ramadhani, Yusnita M. Anggraini
Soil Transmitted Helminth (STH) is a common global helminth infection. Children have a high risk of infection with STH. Indonesia is particularly vulnerable to STH infections due to ideal environmental and socioeconomic conditions in many areas. Nearly, 200 million people across 31 provinces are estimated...
Seroprevalence of Japanese Encephalitis Virus in Pigs and Cattle: An Evaluation from Tangerang Regency
Muhammad U. Riandi, Mara Ipa, Tri Wahono, Joni Hendri, Subangkit, Triwibowo A. Garjito
Japanese encephalitis (JE) is a zoonotic vector-borne disease in humans and animals in the Asia Pacific. This RNA virus is transmitted to humans through mosquito bites from viral amplifiers, such as pigs, poultry, bats, and other vertebrates. In the spread of JEV, herons are considered the reservoir,...
Determinants of Community Distrust of Drugs Deliverers in the Catchment Areas of Waihaong and Air Salobar Health Centers, Ambon
Ezra P. A. Siwtiory, Christiana R. Titaley, Nathalie E. Kailola, Yuniasih M. J. Taihuttu, Bertha J. Que, Chrisia J. Kakisina, Cindy Kamarmir, Alison Krentel
Lymphatic Filariasis (LF) is a chronic infectious disease caused by worms from the nematode group. Mass drug administration (MDA) for LF is carried out in endemic communities to eliminate lymphatic filariasis. Previous analysis shows that one of the factors associated with community compliance with taking...
Update on Human Schistosomiasis Prevalence and Schistosomiasis Control Intervention in Poso Regency, Central Sulawesi Province, Indonesia
Anis N. Widayati, Opyn Mananta
Schistosomiasis in Indonesia is caused by the trematode worm, Schistosoma japonicum, with the snail Oncomelania hupensis lindoensis as its intermediate host. In Indonesia, it spreads in three endemic areas only: Napu and Bada Highlands of Poso Regency and Lindu Highland of Sigi Regency, Sulawesi Tengah...
Detection of Leptospira Bacteria in Rats in Ciomas Sub-district, Bogor District, West Jawa Using Real-Time PCR Method
Gunawan Gunawan, Hanny Zamsiar, Agus A. Wibowo, Yahidin Selian, Dessy L. Utami
Leptospirosis is a zoonotic disease caused by bacteria from the genus Leptospira. Leptospira bacteria can infect rats, dogs, cats, raccoons, cattle, horses, and other mammals. The main reservoir of leptospirosis in Indonesia is rats. Indonesia is a country with a high risk of developing leptospirosis,...
Infestation of Leptospira in Rodents at the Perimeter Area in “Pelabuhan Ratu” Port, Sukabumi District
Marliah Santi, Endang P. Astuti, Yuneu Yuliasih, Mutiara Widawati
Leptospirosis is a neglected zoonotic disease with global health implications. A significant impact of Leptospirosis happens in tropical regions, including Indonesia. Rodents play an essential role in the spread of Leptospirosis due to their rapid population growth and proximity to humans. This study...
N. L. P. I. Dharmayanti, Diana Nurjanah, Teguh Suyatno, Harimurti Nuradji, Suraida Meisari, Risa Indriani
The covid-19 pandemic that occurred in the beginning of 2020 has affected all sectors, particularly in health and economic sectors. The Avian Influenza Virus (AIV), a zoonotic virus that have been reported endemic in Indonesia since 2003, might be affected by this condition. There is very limited information...