The Prevalence of Combined Three Markers of Hepatitis B in Indonesia: Further Analysis of National Basic Health Research, 2013

DOI

10.2991/978-94-6463-112-8_22How to use a DOI?

Keywords

Hepatitis B; HBsAg; anti-HBc; anti-HBs; Indonesia

Abstract

Hepatitis B is still a health problem in the world and Indonesia. A combination of three markers, HBsAg, anti-HBc, and anti-HBs, provides further information on the hepatitis B active infection and immunity status. Therefore, the objective of this study is to identify the prevalence of combined three markers of hepatitis B in the Indonesian population. Serum was collected from respondents aged ≥ 1 year in biomedical testing which was part of the National Basic Health Research conducted by the Ministry of Health in 2013. Up to 37,076 samples were examined for HBsAg, anti-HBc, and anti-HBs using a Chemiluminescent Immunoassay method. Data were then analyzed to calculate the prevalence of the combined three markers of hepatitis B.The result shows that more than half samples were negative (54.23%) and 0.88% were positive for those three markers. The prevalence of only HBsAg positive was found in 1.65% of samples, with positive anti-HBc (3.86%) and anti-HBs (0.40%). Around 22.16% of samples had antibodies both anti-HBc and anti-HBs, 4.52% (only anti-HBc), and 12.29% (only anti-HBs).In summary, most Indonesian populations were still prone to catching hepatitis B and hence need wider access to hepatitis vaccination. The rest had at least a history of hepatitis infection that either might have resolved or still lasted to a chronic state and past vaccination. A small proportion of cases might be suggestive of mutant hepatitis B virus. Therefore, thorough surveillance via genomic sequencing can be performed to identify genotypes of hepatitis virus circulating in our population and help us develop more proper vaccines or targeted therapy for such variants.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Sarwo Handayani
AU  - Frans Dany
PY  - 2023
DA  - 2023/03/01
TI  - The Prevalence of Combined Three Markers of Hepatitis B in Indonesia: Further Analysis of National Basic Health Research, 2013
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 220
EP  - 227
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_22
DO  - 10.2991/978-94-6463-112-8_22
ID  - Handayani2023
ER  -