Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)

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Investigation of Anti-dengue Virus (DeNV) Molecules from a Marine-Derived Bacterium

Authors
Peni Ahmadi1, 3, *, Takahiro Haruyama2, Nobuyuki Kobayashi2, Junichi Tanaka3
1Research Center for Vaccine and Drugs, Research Organization for Health, National Research and Innovation Agency (BRIN), Cibinong, Indonesia
2AVSS Co., Ltd., 1-22 Wakaba-Machi, The Sixth Sanko Bldg., 6F, Nagasaki, 852-8137, Japan
3Department of Chemistry, Biology, and Marine Science, University of the Ryukyus, Nishihara, 903-021, Okinawa, Japan
*Corresponding author. Email: peni.ahmadi@gmail.com
Corresponding Author
Peni Ahmadi
Available Online 1 March 2023.
DOI
10.2991/978-94-6463-112-8_14How to use a DOI?
Keywords
dengue; virus; bioactive compound; marine bacteria
Abstract

Dengue is a viral infection spread by mosquitos that occur in tropical and subtropical areas in the world. Presently, there is no directly acting drug against Dengue Virus (DeNV) for clinical use. Therefore, developing new medicines is required to control the severity of outbreaks. In this proceeding, several bioactive compounds 1–3 isolated from marine-derived bacterium will be reported. Compounds 1–3 were analyzed by several spectrophotometers and concluded as a cyclo(L-Leu-L-pro) (1), nocardamine (2) and cycloheximide (3). Compound 1 showed anti-DeNV activity with IC50 0.38 mg/ml, CC50 6.03 mg/ml, and SI 15.75. Compound 2 exhibited activity against DeNV with IC50 > 10 mg/ml, CC50 7.96 mg/ml, and SI < 0.80. Compound 3 elicited an excellent activity with IC50 0.02 mg/ml, CC50 0.28 mg/ml, and SI 13.70.

Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title
Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
Series
Advances in Health Sciences Research
Publication Date
1 March 2023
ISBN
10.2991/978-94-6463-112-8_14
ISSN
2468-5739
DOI
10.2991/978-94-6463-112-8_14How to use a DOI?
Copyright
© 2023 The Author(s)
Open Access
Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

risenwbib
TY  - CONF
AU  - Peni Ahmadi
AU  - Takahiro Haruyama
AU  - Nobuyuki Kobayashi
AU  - Junichi Tanaka
PY  - 2023
DA  - 2023/03/01
TI  - Investigation of Anti-dengue Virus (DeNV) Molecules from a Marine-Derived Bacterium
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 136
EP  - 148
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_14
DO  - 10.2991/978-94-6463-112-8_14
ID  - Ahmadi2023
ER  -