G6PD Deficiency and Its Correlation to Anaemia Among People Living in High Endemic Malaria Area, Nimbokrang, Papua, Indonesia

DOI

10.2991/978-94-6463-112-8_19How to use a DOI?

Keywords

G6PD; Malaria; asymptomatic anemia; hemolytic anemia; deficiency

Abstract

G6PD deficiency is an X-linked enzymopathy and is the most prevalent genetic disorder in the world, affecting 500 million people, and it frequently causes hemolytic anemia. This genetic disorder is often associated with malaria because of its high prevalence in malaria endemic areas such as Africa, Southeast Asia, and the Pacific region. This research aimed to observe the G6PD deficiency prevalence and its correlation with anemia among people living in Nimbokrang District, since it is one districts with the highest malaria prevalence in Papua, and in Jayapura province is the top-five provinces with highest malaria case in the given province. This research was cross sectional, and 200 participants were randomly chosen and 1 cc of venous blood sample was taken from each participant. Blood samples were then analyzed qualitatively for G6PD deficiency using RDT (HumasisTM) and quantitatively for Hemoglobin level using HemoCue Hb801. The collected data were analyzed using SPSS version 22 for Fischer exact analysis, and a P value < 0.05 was statistically significant. It revealed that 42 out of 200 participants were deficient in G6PD, 19 of whom were males, and the rest were females. The result of Fischer exact analysis showed high significant correlation between G6PD deficiency and low hemoglobin level, and predominantly among female participants. G6PD deficiency was quite prevalent among participants, with a prevalence of 21%, mostly dominated by females with mild to asymptomatic anemia and their correlation was statistically significant with 0.002 of P value.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Download article (PDF)

TY  - CONF
AU  - Muhammad F. Rokhmad
AU  - Yustinus Maladan
AU  - Setyo Adiningsih
AU  - Mirna Widiyanti
AU  - Ivon Ayomi
PY  - 2023
DA  - 2023/03/01
TI  - G6PD Deficiency and Its Correlation to Anaemia Among People Living in High Endemic Malaria Area, Nimbokrang, Papua, Indonesia
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 192
EP  - 199
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_19
DO  - 10.2991/978-94-6463-112-8_19
ID  - Rokhmad2023
ER  -