Effect of Ardisia elliptica Thunb. on Diabetes Mellitus Type 2 Rat Models

Kurnia Agustini; Idah Rosidah; Ngatinem Ngatinem; Sri Ningsih; Julham Effendi; Muhammad Amin; Bhintarti Suryohastari

doi:10.2991/978-94-6463-112-8_65

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Effect of Ardisia elliptica Thunb. on Diabetes Mellitus Type 2 Rat Models

Authors

Kurnia Agustini¹^{, *}, Idah Rosidah¹, Ngatinem Ngatinem¹, Sri Ningsih¹, Julham Effendi¹, Muhammad Amin², Bhintarti Suryohastari²

¹Research Center for Pharmaceutical Ingredient and Traditional Medicine, National Research and Innovation Agency (BRIN), South Tangerang, Indonesia

²Departemen of Biology, Faculty of Science and Technology, State Islamic University of Syarif Hidayatullah, Jakarta, Indonesia

^*Corresponding author. Email: urnia.agustini@brin.go.id

Corresponding Author

Kurnia Agustini

Available Online 1 March 2023.

DOI: 10.2991/978-94-6463-112-8_65 How to use a DOI?
Keywords: Ardisia elliptica; Diabetes Mellitus Type2; High Fat Diet; Streptozotocin; Pancreas
Abstract: Ardisia elliptica is one of Indonesian medicinal plants known as Lampeni. Some studies proved that Ardisia elliptica has activities as antibacterial, antiviral, antiplatelet, antiplasmodial and antiproliferative in cancer cell line. Its leaves contain some phytochemical compounds such as α-amyrin, β-amyrin and Bergenin. The aim of this study was to investigate the effect of Ardisia elliptica ethanolic extract (AEE) on Spraque Dawley rats induced by high fat diet (HFD) and streptozotocin (STZ). These models represent DM type 2 conditions. Animals were divided into six groups, namely normal group, negative control group, positive control group (treat with Metformin) and three level doses of AEE (20 mg/200 gBW; 40 mg/200 gBW and 80 mg/200 gBW). All animals were fed with HFD every day. After acclimatization, animals were induced by STZ 6 mg/200 gBW intraperitoneally. Samples were given 7 days after induction until day 21. Blood glucose level were analysed at day 0, 4, 7, 10, 14 and 21 after sample treatment. Histopathological analyses were done for pancreas organ. The result showed that at day 4, AEE start on 20 mg/200 gBW could decrease blood glucose level significantly (p < 0.05). After 21 days treatment, AEE on 80 mg/200 gBW gave the best effect by decrease blood glucose level until 39%, while on Dose 1 (20 mg/200 gBW) could decrease 22% and on Dose 2 (40 mg/200 gBW) could decrease 28%. Histopathological analyses of pancreas organ showed that AEE could increase the number of β-cell, 48% on Dose 1, 53% on Dose 2 and 37% on Dose 3. This study concluded that Ardisia elliptica has potency to treat Diabetes Mellitus Type2.
Copyright: © 2023 The Author(s)
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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Volume Title: Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
Series: Advances in Health Sciences Research
Publication Date: 1 March 2023
ISBN: 10.2991/978-94-6463-112-8_65
ISSN: 2468-5739
DOI: 10.2991/978-94-6463-112-8_65 How to use a DOI?
Open Access: Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

Cite this article

ris enw bib

TY  - CONF
AU  - Kurnia Agustini
AU  - Idah Rosidah
AU  - Ngatinem Ngatinem
AU  - Sri Ningsih
AU  - Julham Effendi
AU  - Muhammad Amin
AU  - Bhintarti Suryohastari
PY  - 2023
DA  - 2023/03/01
TI  - Effect of Ardisia elliptica Thunb. on Diabetes Mellitus Type 2 Rat Models
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 719
EP  - 728
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_65
DO  - 10.2991/978-94-6463-112-8_65
ID  - Agustini2023
ER  -

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