Analysis of Sea Cucumber Metabolites as Phytate Inhibitor in Human ZiP Transporter: Molecular Docking Study

DOI

10.2991/978-94-6463-112-8_7How to use a DOI?

Keywords

sea cucumber; inhibitor; Phytate; ZiP transporter; molecular docking

Abstract

One of the causes of zinc deficiency is decreased zinc intake or impaired absorption of zinc which causes zinc bioavailability to decrease in the blood. Phytate is one of the compounds found in food that can interfere with zinc absorption in the human digestive system. The formation of a zinc complex with phytate affects zinc absorption through the human ZiP transporter (hZiP). Sea cucumber has also long been used as a dietary supplement in the East Asian region which helps maintain body health. However, there has not been much research on the potential of sea cucumber metabolites as phytate inhibitors that inhibit zinc absorption in the digestive system. The result obtained from molecular docking is that sea cucumber metabolite has the potential to inhibit the binding of phytates in ZiP2 and ZiP4 membrane proteins that act as zinc transporters from extracellular to intracellular. The metabolites in sea cucumber that have the potential as phytate inhibitors in the ZiP2 membrane protein are Holothurin, Arguside, Miliariside, Nobiliside, and Virescenoside. In the smoldering protein ZiP4, the six compounds also have the potential to inhibit phytate. Based on the molecular docking analysis, holothurin has potency as a phytate inhibitor, evidenced by binding energy and conformation in the binding site. Visualization analysis described that the holothurin precisely binds in phytate binding site in protein receptor. In addition, literature reported, that holothurin has potency as antiviral, antibacterial, and anticancer. The sea cucumber with active metabolites is one of the important marine commodities for maintaining human health and supplementation nutrition.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Gita Syahputra
AU  - Nunik Gustini
AU  - Melva Louisa
AU  - Fadilah Fadilah
AU  - Masteria Y. Putra
PY  - 2023
DA  - 2023/03/01
TI  - Analysis of Sea Cucumber Metabolites as Phytate Inhibitor in Human ZiP Transporter: Molecular Docking Study
BT  - Proceedings of the 1st International Conference for Health Research – BRIN (ICHR 2022)
PB  - Atlantis Press
SP  - 65
EP  - 74
SN  - 2468-5739
UR  - https://doi.org/10.2991/978-94-6463-112-8_7
DO  - 10.2991/978-94-6463-112-8_7
ID  - Syahputra2023
ER  -