Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

Gene Polymorphism of DNA Excision Repair in Pathogenesis of Malignancy

Authors
P. Dzhambetova, Z. Bisultanova, M. Atsayeva
Corresponding Author
P. Dzhambetova
Available Online October 2019.
DOI
10.2991/ichw-19.2019.18How to use a DOI?
Keywords
gene polymorphism, repair genes, XPC, XPA , ERCC2, breas cancer, Chechen population.
Abstract

The interaction towards a risk of breast cancer in the ethnically homogeneous group of the Chechens and the polymorphism of DNA repair genes was studied: XPC (rs2228000, rs2228001) XPA (rs 1800975) ERCC2 (rs13181; rs1799793). DNA samples taken from venous blood of 241 women diagnosed with breast cancer and of other 300 representatives of a control group were used. According to the study, no significant connection was found between the alleles of the studied polymorphisms of DNA repair and breast cancer genes; the exception is in a minor allele of ERCC2 rs13181 gene (OR = 1.33 with 95 % CI 1.06 - 1.79). However, regression analysis revealed some significant links (p <0.05) between XPC rs2228000 polymorphism and a risk in developing breast cancer OR = 4.80 (95 % CI 1.56 - 14.78) and OR = 8.95 (95 % CI 2.92 - 27.44), respectively. Also, reliable connections were noted for recessive model AA / CA + CC of the XPC gene (rs2228001): OR = 0.63 (95 % CI 0.40 - 0.98). Likewise, some significant associations (p <0.05) were observed in TT / TG + GG recessive models of polymorphic variants of ERCC2 rs13181 OR = 2.39 95 % CI 1.30 - 4.39 and AA / AG + GG rs1799793 (OR = 2.26 95 % CI 1.33 - 3.83). The experiment results showed that recessive GG homozygote raises a possibility towards breast tumor formations (OR = 2.39 with 95 % CI 1.30 - 4.39) and can be used in a diagnostic panel to determine a risk rate in breast cancer in the Chechen population.

Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
Series
Advances in Health Sciences Research
Publication Date
October 2019
ISBN
10.2991/ichw-19.2019.18
ISSN
2468-5739
DOI
10.2991/ichw-19.2019.18How to use a DOI?
Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - P. Dzhambetova
AU  - Z. Bisultanova
AU  - M. Atsayeva
PY  - 2019/10
DA  - 2019/10
TI  - Gene Polymorphism of DNA Excision Repair in Pathogenesis of Malignancy
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 73
EP  - 76
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.18
DO  - 10.2991/ichw-19.2019.18
ID  - Dzhambetova2019/10
ER  -