Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

Mutation Frequency in BRCA1 And BRCA2 Genes Among Women with Breast Cancer in Kabardino-Balkaria

Authors
M. Bittueva, P. Dzhambetova, D. Hashhozheva, Z. Bogotova, T. Handohov
Corresponding Author
M. Bittueva
Available Online October 2019.
DOI
10.2991/ichw-19.2019.19How to use a DOI?
Keywords
breast cancer (BC) gene BRCA1, gene BRCA2, heriditary susceptibility, Kabardino-Balkaria
Abstract

The study was conducted within the individual genotyping of healthy and sick women in the Kabardino-Balkarian Republic to determine the risk-prone groups with increased susceptibility to hereditary form of breast cancer development. Blood samplings were collected and total DNA was taken from 300 people (control and experimental groups). The frequency of 5382insC, 4154delA, 185delAG BRCA1 mutations and 6174delT mutations of the BRCA2 gene among women with breast cancer was studied. The data obtained along with the survey suggest the hereditary or sporadic nature of the disease. A comparative analysis of the frequencies of genes alleles towards susceptibility to the hereditary form of this disease will provide an opportunity to discover the genetic reasons for an increase in cancer and to identify the groups of the greatest risk.

Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
Series
Advances in Health Sciences Research
Publication Date
October 2019
ISBN
10.2991/ichw-19.2019.19
ISSN
2468-5739
DOI
10.2991/ichw-19.2019.19How to use a DOI?
Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - M. Bittueva
AU  - P. Dzhambetova
AU  - D. Hashhozheva
AU  - Z. Bogotova
AU  - T. Handohov
PY  - 2019/10
DA  - 2019/10
TI  - Mutation Frequency in BRCA1 And BRCA2 Genes Among Women with Breast Cancer in Kabardino-Balkaria
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 77
EP  - 80
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.19
DO  - 10.2991/ichw-19.2019.19
ID  - Bittueva2019/10
ER  -