Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

Polymorphic Variants of Genes RAD51B and XRCC1 Influence on Breast Cancer Development

Authors
Z. Bisultanova, M. Bittueva, P. Dzhambetova, L. Dzhambetova, E. Machogov
Corresponding Author
Z. Bisultanova
Available Online October 2019.
DOI
https://doi.org/10.2991/ichw-19.2019.20How to use a DOI?
Keywords
gene polymorphism, repair genes, XRCC1, RAD51B, breast cancer, Chechen population
Abstract

The present work studies the polymorphic variants of XRCC1 (rs1799782) and RAD51B (rs10483813) genes, which are associated with the risk in developing a number of oncology diseases, particularly it relates to women with breast cancer, the place as location of their living we consider the Chechen Republic. A reliably significant risk for breast cancer development was detected, if 470T> C gene XRCC1 polymorphism among women (p = 0.04) is presented, which indicates the mutation involvement in malignancy pathogenesis. The RAD51 gene family plays the critical roles in the extensive genetic instability caused by the loss of their activity. The missense-variant A> G of RAD51B was identified in two cases among the patients (5.8 %) and two healthy women (2.7 %). The analysis towards the correlation of this mutation with malignant transformation of breast cells showed the significance of the minor G allele in odds ratio (OR = 2.04 with 95 % CI = 0.29-14.51). However, the differences did not reach the statistical meaning (p> 0.621).

Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
Series
Advances in Health Sciences Research
Publication Date
October 2019
ISBN
978-94-6252-820-8
ISSN
2468-5739
DOI
https://doi.org/10.2991/ichw-19.2019.20How to use a DOI?
Copyright
© 2019, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

TY  - CONF
AU  - Z. Bisultanova
AU  - M. Bittueva
AU  - P. Dzhambetova
AU  - L. Dzhambetova
AU  - E. Machogov
PY  - 2019/10
DA  - 2019/10
TI  - Polymorphic Variants of Genes RAD51B and XRCC1 Influence on Breast Cancer Development
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 81
EP  - 83
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.20
DO  - https://doi.org/10.2991/ichw-19.2019.20
ID  - Bisultanova2019/10
ER  -