Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)

The Effect of the Course Intake of Hilak Mineral Water on Liver Function in Experimental Toxic Hepatitis and Intrahepatic Cholestasis

Authors
I.G. Dzhioev, F.E. Batagova, O.V. Remizov, E.A. Gutsaeva, I.I. Akhmadov
Corresponding Author
I.G. Dzhioev
Available Online October 2019.
DOI
https://doi.org/10.2991/ichw-19.2019.21How to use a DOI?
Keywords
hilak mineral, hepatitis, intrahepatic cholestasis, liver
Abstract
The effect of a two-week intake of bicarbonate carbon dioxide-sodium chloride mineral water of North Ossetia "Hilak" with a total mineralization of 2.1-2.3 g/l on the functional state of the liver of Wistar rats with toxic hepatitis and intrahepatic cholestasis was studied. Toxic hepatitis was modeled by triple intragastric administration of carbon tetrachloride in a dose of 1.5 ml/kg on 42 rats, and intrahepatic cholestasis also in 42 rats by a single intragastric administration of ?-naphthilisothiocyanate at a dose of 100 mg/kg. The introduction of carbon tetrachloride in three days causes an increase in blood bilirubin, alkaline phosphatase and alanine aminotransferase activity, a decrease in cholesterol, hemoglobin, red blood cell count, hematocrine number and de Rytis coefficient. The two-week constant free intake of Hilak mineral water had a normalizing effect on the studied parameters. In experimental intrahepatic cholestasis, after 72 hours, there is an increase in the blood content of cholesterol, bilirubin and alkaline phosphatase. The preventive and therapeutic intake of mineral water, when rats had free access to mineral water for two weeks, then ?-naphthylisothiocyanate was introduced to them and after three days they received mineral water, had the most positive effect. Conducting further research may allow recommending the intake of Hilak mineral water as a therapeutic agent for patients with liver pathology.
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This is an open access article distributed under the CC BY-NC license.

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Volume Title
Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
Series
Advances in Health Sciences Research
Publication Date
October 2019
ISBN
978-94-6252-820-8
ISSN
2468-5739
DOI
https://doi.org/10.2991/ichw-19.2019.21How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - I.G. Dzhioev
AU  - F.E. Batagova
AU  - O.V. Remizov
AU  - E.A. Gutsaeva
AU  - I.I. Akhmadov
PY  - 2019/10
DA  - 2019/10
TI  - The Effect of the Course Intake of Hilak Mineral Water on Liver Function in Experimental Toxic Hepatitis and Intrahepatic Cholestasis
BT  - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019)
PB  - Atlantis Press
SP  - 84
EP  - 87
SN  - 2468-5739
UR  - https://doi.org/10.2991/ichw-19.2019.21
DO  - https://doi.org/10.2991/ichw-19.2019.21
ID  - Dzhioev2019/10
ER  -