The Effect of the Course Intake of Hilak Mineral Water on Liver Function in Experimental Toxic Hepatitis and Intrahepatic Cholestasis
I.G. Dzhioev, F.E. Batagova, O.V. Remizov, E.A. Gutsaeva, I.I. Akhmadov
Available Online October 2019.
- https://doi.org/10.2991/ichw-19.2019.21How to use a DOI?
- hilak mineral, hepatitis, intrahepatic cholestasis, liver
- The effect of a two-week intake of bicarbonate carbon dioxide-sodium chloride mineral water of North Ossetia "Hilak" with a total mineralization of 2.1-2.3 g/l on the functional state of the liver of Wistar rats with toxic hepatitis and intrahepatic cholestasis was studied. Toxic hepatitis was modeled by triple intragastric administration of carbon tetrachloride in a dose of 1.5 ml/kg on 42 rats, and intrahepatic cholestasis also in 42 rats by a single intragastric administration of ?-naphthilisothiocyanate at a dose of 100 mg/kg. The introduction of carbon tetrachloride in three days causes an increase in blood bilirubin, alkaline phosphatase and alanine aminotransferase activity, a decrease in cholesterol, hemoglobin, red blood cell count, hematocrine number and de Rytis coefficient. The two-week constant free intake of Hilak mineral water had a normalizing effect on the studied parameters. In experimental intrahepatic cholestasis, after 72 hours, there is an increase in the blood content of cholesterol, bilirubin and alkaline phosphatase. The preventive and therapeutic intake of mineral water, when rats had free access to mineral water for two weeks, then ?-naphthylisothiocyanate was introduced to them and after three days they received mineral water, had the most positive effect. Conducting further research may allow recommending the intake of Hilak mineral water as a therapeutic agent for patients with liver pathology.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - I.G. Dzhioev AU - F.E. Batagova AU - O.V. Remizov AU - E.A. Gutsaeva AU - I.I. Akhmadov PY - 2019/10 DA - 2019/10 TI - The Effect of the Course Intake of Hilak Mineral Water on Liver Function in Experimental Toxic Hepatitis and Intrahepatic Cholestasis BT - Proceedings of the International Conference on Health and Well-Being in Modern Society (ICHW 2019) PB - Atlantis Press SP - 84 EP - 87 SN - 2468-5739 UR - https://doi.org/10.2991/ichw-19.2019.21 DO - https://doi.org/10.2991/ichw-19.2019.21 ID - Dzhioev2019/10 ER -