Proceedings of the 2016 4th International Conference on Machinery, Materials and Computing Technology

Synthesis of 3-chloro-2-oxo-butanoate

Authors
Yuanbiao Tu, Yuping Guo, Min Wang, Wufu Zhu, Shan Xu
Corresponding Author
Yuanbiao Tu
Available Online March 2016.
DOI
https://doi.org/10.2991/icmmct-16.2016.150How to use a DOI?
Keywords
3-Chloro-2-oxo-butanoate, Synthesis
Abstract
3-chloro-2-oxo-butyric acid ethyl ester 5 is an important intermediate in many biologically active compounds such as thiazole carboxylic acids. In this work, a rapid synthetic method for compound 5 was established. The compound 5 was synthesized from the commercially available diethyl oxalate through two steps including nucleophilic substitution, chlorinated. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the two steps was30%
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Volume Title
Proceedings of the 2016 4th International Conference on Machinery, Materials and Computing Technology
Series
Advances in Engineering Research
Publication Date
March 2016
ISBN
978-94-6252-165-0
ISSN
2352-5401
DOI
https://doi.org/10.2991/icmmct-16.2016.150How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Yuanbiao Tu
AU  - Yuping Guo
AU  - Min Wang
AU  - Wufu Zhu
AU  - Shan Xu
PY  - 2016/03
DA  - 2016/03
TI  - Synthesis of 3-chloro-2-oxo-butanoate
BT  - Proceedings of the 2016 4th International Conference on Machinery, Materials and Computing Technology
PB  - Atlantis Press
SP  - 769
EP  - 771
SN  - 2352-5401
UR  - https://doi.org/10.2991/icmmct-16.2016.150
DO  - https://doi.org/10.2991/icmmct-16.2016.150
ID  - Tu2016/03
ER  -