Synthesis of 3-chloro-2-oxo-butanoate
- 10.2991/icmmct-16.2016.150How to use a DOI?
- 3-Chloro-2-oxo-butanoate, Synthesis
3-chloro-2-oxo-butyric acid ethyl ester 5 is an important intermediate in many biologically active compounds such as thiazole carboxylic acids. In this work, a rapid synthetic method for compound 5 was established. The compound 5 was synthesized from the commercially available diethyl oxalate through two steps including nucleophilic substitution, chlorinated. The structure was confirmed by MS and 1HNMR. Furthermore, the synthetic method was optimized. The total yield of the two steps was30%
- © 2016, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Yuanbiao Tu AU - Yuping Guo AU - Min Wang AU - Wufu Zhu AU - Shan Xu PY - 2016/03 DA - 2016/03 TI - Synthesis of 3-chloro-2-oxo-butanoate BT - Proceedings of the 2016 4th International Conference on Machinery, Materials and Computing Technology PB - Atlantis Press SP - 769 EP - 771 SN - 2352-5401 UR - https://doi.org/10.2991/icmmct-16.2016.150 DO - 10.2991/icmmct-16.2016.150 ID - Tu2016/03 ER -