Bats As A Viral Reservoir: A Short Review Of Their Ecological Characters And Immune System

DOI

10.2991/icoh-17.2018.25How to use a DOI?

Keywords

chiropterans, reservoir, flying mammal, zoonosis, immunology

Abstract

Bats are reported as natural reservoir host of several viruses, many of which cause severe human disease. Infected bats usually do not show any clinical symptoms and persistently infected. Bats immunity against viruses is an evolutional process of self-defense created by ecological adaptation between host and pathogen. Bats have unique characters which support them as a viral reservoir, whereas RNA viruses which are commonly carried by bats take an advantage of these characteristics to survive. The role of bats as reservoirs is also supported by several differences of immune system than other mammals. Several studies on molecular factors of bats immune system lead to a hypothesis that bats are able to control viral replication very early in the immune response through innate antiviral mechanism. However, to complete understanding of the nature of immune responses of bats to the virus still needs a lot of study. Advance technology on molecular techniques revealed the immune factors and provided numerous data about molecular factors in bat immunity, however comprehensive studies about morphology of bats immune organs are still lacking. One of the important immune organs which have functional variations due to their structural differences between species is the spleen, which will be our main focus of study in the future. We hope that the result of our study will be able to provide the database on the morphology and physiology of bat spleen and give better understanding on bats immune system.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Desrayni Hanadhita
AU  - Aryani Sismin Satyaningtijas
AU  - Srihadi Agung Priyono
PY  - 2017/07
DA  - 2017/07
TI  - Bats As A Viral Reservoir: A Short Review Of Their Ecological Characters And Immune System
BT  - Proceedings of the 1st International Conference in One Health (ICOH 2017)
PB  - Atlantis Press
SP  - 124
EP  - 128
SN  - 2468-5739
UR  - https://doi.org/10.2991/icoh-17.2018.25
DO  - 10.2991/icoh-17.2018.25
ID  - Hanadhita2017/07
ER  -