Antifertility Effect of Centella asiatica (L) Urban and Plucea indica (L) Urban on the Number of Follicles, Antioxidant Activity and Hormonal Profile of White Rat's Ovaries

DOI

10.2991/icoh-17.2018.46How to use a DOI?

Keywords

Centella asiatica, Plucea indica, Number of follicles, Antioxidant activity, Hormonal profile

Abstract

Antifertility agents with safety and effectiveness in terms of minimum side effects have always been a subject of debate. Many studies have been conducted on plants to observe the antifertility effect, but majority of them were toxic. Centella asiaticaÿand Plucea indica leaves have been traditionally used as medicine for its properties to promote antifertility effect. The objective of the present study was to investigate the combination effects ofÿC. asiaticaÿand P. indica leaf extract to the number of follicles, antioxidant activity, and hormonal profile of female rats. Thirty two fertile female rats (2 months), were divided into six groups and treated with different formula of the combination of C. asiaticaÿand P. indica leaf extract: group 1 (T1) with 25 + 25 mg/kg bw, group 2 (T2) with 50 + 50 mg/kg bw, group 3 (T3) with 75 + 75 mg/kg bw, group 4 (T4) with 125 + 125 mg/kg bw, (T5) group 5 with 200 + 200 mg/kg bw, and control group (T0) treated with only 0,5% Na CMC. They were also fed for 42 days. The rat's blood serum was taken for hormonal analysis, as well they were sacrificed and the ovarium were removed for histological and antioxidant analysis. The results revealed that C. asiaticaÿand P. indica leaf extract influences to the number of follicles, antioxidant activity and hormonal profile of the rats. Group 4 (T4) showed the highest antifertility effect on the ovulation number (corpus lutium), total of ovarian follicles, and level of estrogen, respectively. Group 5 (T5) showed the highes level of superoxide dismutase (SOD) and the lowest level of Malondialdehide (MDA). It is concluded that C. asiaticaÿand P. indica exhibited antifertility effects on reproductive system of the female rats.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Bayyinatul Muchtaromah
AU  - Mukholifah Mukholifah
AU  - Ihda Sayidatun Nasiroh
AU  - Mujahidin Ahmad
AU  - Romaidi Romaidi
PY  - 2017/07
DA  - 2017/07
TI  - Antifertility Effect of Centella asiatica (L) Urban and Plucea indica (L) Urban on the Number of Follicles, Antioxidant Activity and Hormonal Profile of White Rat's Ovaries
BT  - Proceedings of the 1st International Conference in One Health (ICOH 2017)
PB  - Atlantis Press
SP  - 235
EP  - 240
SN  - 2468-5739
UR  - https://doi.org/10.2991/icoh-17.2018.46
DO  - 10.2991/icoh-17.2018.46
ID  - Muchtaromah2017/07
ER  -