The Comparative Effects of Branded and Local High Fat Foods on Body Mass Index and Vascular Wall Thickness in Male Wistar Rats for Development of Atherosclerosis Animal Model

DOI

10.2991/978-94-6463-062-6_58How to use a DOI?

Keywords

Atherosclerosis; High fat diet; Vascular wall thickness (VWT); BMI

Abstract

Cardiovascular diseases are the leading cause of mortality over the world, which is approximately 17.9 million patients’ death in 2019 or 32% of all deaths worldwide. Atherosclerosis formation due to accumulated plaques in the tunica intima of vascular walls underlies the pathogenesis of cardiovascular diseases. Inactive life style and bad diet are the major risk factors of these diseases. This study investigated the different effect of high-fat diets on body mass index (BMI), lipid profile and vascular wall thickness (VWT) in rats model atherosclerosis. A total of 10 male Wistar rats were used in this experimental study. The Wistar rats were randomly divided into two groups (A and B). Group A was fed by the DYETs food while group B were given local high fat foods. The BMI was calculated using body weight (BW) and body length. Internal carotid artery thickness was measured using a linear ultrasound. The t-tests were performed to compare within and between groups. There was a significant difference in carotid artery thickness between two groups with p < 0.05 but the mean BMI of group A did not differ from the mean BMI of group B with p > 0.05. In conclusion, A local high fat diet has a similar effect in obesity induction of male Wistar rats, compared to DYETs diet although a higher increased internal carotid artery thickness is detected in the later diet. Further research is required to identify histopathologically the plaque structure.

Copyright

© 2023 The Author(s)

Open Access

Open Access This chapter is licensed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), which permits any noncommercial use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license and indicate if changes were made.

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TY  - CONF
AU  - Prasetyo Sarwono Putro
AU  - Dono Indarto
AU  - Bambang Purwanto
AU  - Widiastuti Soewondo
AU  - Sulistyani Kusumaningrum
PY  - 2022
DA  - 2022/12/22
TI  - The Comparative Effects of Branded and Local High Fat Foods on Body Mass Index and Vascular Wall Thickness in Male Wistar Rats for Development of Atherosclerosis Animal Model
BT  - Proceedings of the 4th International Conference on Life Sciences and Biotechnology (ICOLIB 2021)
PB  - Atlantis Press
SP  - 572
EP  - 578
SN  - 2468-5747
UR  - https://doi.org/10.2991/978-94-6463-062-6_58
DO  - 10.2991/978-94-6463-062-6_58
ID  - Putro2022
ER  -