The Potential Effect of Citrus Sinensis Extract on Malondialdehyde (MDA) Levels in Rat Induced by Cigarette Smoke

DOI

10.2991/ahsr.k.210115.083How to use a DOI?

Keywords

cigarette smoke, Citrus sinensis, MDA, Rattus Norvergicus

Abstract

Cigarette smoke contains numerous substances containing free radicals and can prompt oxidative pressure. The buildup of free radicals cannot be neutralized by antioxidants for essential cancer prevention agent supplements from outside. In relation to that, the peel of citrus sinensis is expected to contain cell reinforcements that may eliminate free radicals. This study aims to determine the potential effect of Citrus sinensis peel extract on MDA levels in rats induced by cigarette smoke. This investigation is an experimental study with pre and post-test control groups. The 25 subjects of Rattus Norvergicus were divided into five groups: normal group, positive group, Treatment 1 (37.5 mg/kg BW Citrus sinensis peel extract), Treatment 2 (75 mg/kg BW Citrus sinensis peel extract) and Treatment 3 (112.5 mg/kg BW Citrus sinensis peel extract). Analysis of statistics resulted in a huge distinction between pre-test and post-test with p-value <0.05 (Wilcoxon test). Consequently, the Kruskal-Wallis was applied to distinguish the expansion of MDA levels pre-test and post-test. The investigation showed that the distinction was in the most significant levels in the positive group (7.71 nmol/mL), the least in the negative group (0.09 nmol/mL), and 37.5 mg/kg Citrus sinensis peel extract group (0.96 nmol/mL) was the most reduced among the treatment groups. There are huge contrasts in all treatment groups with p = 0.000 (p <0.05). The investigation inferred that the concentrate of Citrus sinensis could lessen levels of MDA in Rattus Norvergicus prompted by cigarette smoke.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ika Setyawati
AU  - Nunki Indah Hidayati
PY  - 2021
DA  - 2021/01/16
TI  - The Potential Effect of Citrus Sinensis Extract on Malondialdehyde (MDA) Levels in Rat Induced by Cigarette Smoke
BT  - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
PB  - Atlantis Press
SP  - 417
EP  - 419
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210115.083
DO  - 10.2991/ahsr.k.210115.083
ID  - Setyawati2021
ER  -