Evaluation of Potential Drug-Drug Interactions in Hypercholesterolemia Patients at Teaching Hospital Surabaya

DOI

10.2991/ahsr.k.210115.064How to use a DOI?

Keywords

Drug interactions, pDDIs, Pharmacokinetic, Pharmacodynamics, Hypercholesterolemia

Abstract

Drug-drug interactions increase the effectiveness of therapy but can also have undesirable effects on toxicity. A pharmacist has the responsibility to prevent the undesirable effect of drug-drug interactions. The purpose of this study was to evaluate the potential drug-drug interactions in hypercholesterolemia patients at Teaching Hospital Surabaya. This study was conducted with a prospective method for a month. We obtained 54 patients and identified 45 patients that have potential drug-drug interactions. The total potential drug-drug interactions were 101. The severity of potential drug-drug interactions is serious (24,7%) and moderate (75,3%). Based on the mechanism action of drug interactions are pharmacodynamics (59,4%), pharmacokinetics (32,7%), and unknown (7,9%). The role of the pharmacist in providing safe, effective and rational drug therapy can be done by either identifying drug interactions, prevent and minimize the negative effect of drug interactions.

Copyright

© 2021, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Ana Khusnul Faizah
AU  - Nani Wijayanti Dyah Nurrahman
PY  - 2021
DA  - 2021/01/16
TI  - Evaluation of Potential Drug-Drug Interactions in Hypercholesterolemia Patients at Teaching Hospital Surabaya
BT  - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
PB  - Atlantis Press
SP  - 302
EP  - 304
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210115.064
DO  - 10.2991/ahsr.k.210115.064
ID  - Faizah2021
ER  -