Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)

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Effectiveness of Anting-Anting Leaves (Acalypha indica L.) in Reducing Uric Acid Levels in Hyperuricemic Male White Rats (Rattus novergicus)

Authors
Sefi Megawati, Saru Noliqo Rangkuti, Sagita Novianti
Corresponding Author
Sefi Megawati
Available Online 16 January 2021.
DOI
10.2991/ahsr.k.210115.104How to use a DOI?
Keywords
Allopurinol, Gout, Anting-Anting Leaves
Abstract

Hyperuricemia is an elevated level of uric acid in the blood that induces uric acid needle shaped crystals saturation resulting in joint stiffness. Anting-anting leaf contains quercetin and kaempferol which are capable of decreasing uric acid in the body. The purpose of this study was to determine the effect of ethanol extract of anting-anting leaves (Acalypha indica L.) in decreasing uric acid levels in male rats Sprague Dawley induced by caffeine. This is an experimental research using 25 male rats, which were divided into 5 groups: negative, positive group, and three groups given the extract dose of 3.15 g/BW, 6.3 g/BW and 12.6 g/BW. Data were obtained from the examination of normal levels of uric acid, the level of uric after induction and the level after the treatment. Data were analyzed using one-way ANOVA. The test results showed that ethanol extracts of anting-anting leaf dose of 12.6 g/BW could significantly decrease uric acid levels in male rats’ blood that was induced by caffeine dose of 5.29 mg/200gBW and was equivalent to the level of positive control (allopurinol 1.8 mg/200gBW). It is concluded that ethanol 96% extract of anting-anting leaf (Acalypha indica L.) has an effective effect in decreasing uric acid.

Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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Volume Title
Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
Series
Advances in Health Sciences Research
Publication Date
16 January 2021
ISBN
10.2991/ahsr.k.210115.104
ISSN
2468-5739
DOI
10.2991/ahsr.k.210115.104How to use a DOI?
Copyright
© 2021, the Authors. Published by Atlantis Press.
Open Access
This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

Cite this article

risenwbib
TY  - CONF
AU  - Sefi Megawati
AU  - Saru Noliqo Rangkuti
AU  - Sagita Novianti
PY  - 2021
DA  - 2021/01/16
TI  - Effectiveness of Anting-Anting Leaves (Acalypha indica L.) in Reducing Uric Acid Levels in Hyperuricemic Male White Rats (Rattus novergicus)
BT  - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020)
PB  - Atlantis Press
SP  - 534
EP  - 537
SN  - 2468-5739
UR  - https://doi.org/10.2991/ahsr.k.210115.104
DO  - 10.2991/ahsr.k.210115.104
ID  - Megawati2021
ER  -