Affinity of Compounds in Hemigraphis Alternata (Burm.F.) T. Ander Leaves to Cyclooxygenase 1 (COX-1): In Silico Approach
- DOI
- 10.2991/ahsr.k.210115.107How to use a DOI?
- Keywords
- Hemigraphis alternata, Cyclooxygenase 1, In silico
- Abstract
Inflammation is an important biological process for eradicating pathogens and maintaining tissue homeostasis. Cyclooxygenase 1 (COX-1) is one of the pharmacological targets for anti-inflammatory drugs. The purposes of this study was to predict the affinity of 23 compounds contained in Hemigraphis alternata leaves in inhibiting COX-1. The compounds of Hemigraphis alternata leaves were screened for its affinity towards COX-1 using docking software, DOCK 6.9, with aspirin as the reference. Based on the Grid score, the greatest binding affinity is referred to 3,7,11,15-tetramethyl-2-hexadecen-1-ol. It is better than affinity of aspirin to COX-1. The study showed that Hemigraphis alternata leaves contain potential active components that could be developed as COX-1-inhibitor.
- Copyright
- © 2021, the Authors. Published by Atlantis Press.
- Open Access
- This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).
Cite this article
TY - CONF AU - Yeni Yeni AU - Rizky Arcinthya Rachmania AU - Dicky Yanuar M R Mochamad PY - 2021 DA - 2021/01/16 TI - Affinity of Compounds in Hemigraphis Alternata (Burm.F.) T. Ander Leaves to Cyclooxygenase 1 (COX-1): In Silico Approach BT - Proceedings of the 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020) PB - Atlantis Press SP - 552 EP - 555 SN - 2468-5739 UR - https://doi.org/10.2991/ahsr.k.210115.107 DO - 10.2991/ahsr.k.210115.107 ID - Yeni2021 ER -