2nd International Conference On Systems Engineering and Modeling (ICSEM-13)

Using Fuzzy logic to Adjust Plasma Concentration Based on a Two-compartment Pharmacokinetic Model

Authors
Lei Zhao, Xinling Shi, Yufeng Zhang, Yajie Liu
Corresponding Author
Lei Zhao
Available Online April 2013.
DOI
https://doi.org/10.2991/icsem.2013.139How to use a DOI?
Keywords
fuzzy logic, fuzzy controller, pharmacokinetic model, parameter adaption
Abstract
In this paper, a closed-loop control system was developed using fuzzy logic to adapt the parameters of a pharmacokinetic (PK) model. The system is based on a two-compartment PK model with first-order rate process of oral administration. The fuzzy logic adaptation scheme uses the error and the change in error as the input variables. The output variable of the fuzzy controller is the scaling factor to adjust the PK parameter. The fuzzy controller adjusted the real situation concentration to the reference value derived from the parameters of population mean data according to the established rule-base. The simulation results show that the controller provides good performance to adjust the concentration with the reference values.
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This is an open access article distributed under the CC BY-NC license.

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Proceedings
2nd International Conference On Systems Engineering and Modeling (ICSEM-13)
Part of series
Advances in Intelligent Systems Research
Publication Date
April 2013
ISBN
978-94-91216-42-8
ISSN
1951-6851
DOI
https://doi.org/10.2991/icsem.2013.139How to use a DOI?
Open Access
This is an open access article distributed under the CC BY-NC license.

Cite this article

TY  - CONF
AU  - Lei Zhao
AU  - Xinling Shi
AU  - Yufeng Zhang
AU  - Yajie Liu
PY  - 2013/04
DA  - 2013/04
TI  - Using Fuzzy logic to Adjust Plasma Concentration Based on a Two-compartment Pharmacokinetic Model
BT  - 2nd International Conference On Systems Engineering and Modeling (ICSEM-13)
PB  - Atlantis Press
SN  - 1951-6851
UR  - https://doi.org/10.2991/icsem.2013.139
DO  - https://doi.org/10.2991/icsem.2013.139
ID  - Zhao2013/04
ER  -