Hormonal and Genetic Role Affecting the Bone Resorption in Patients with Osteoporosis
Susi R. Puspitadewi, Elza I. Auerkari
Susi R. Puspitadewi
Available Online February 2018.
- https://doi.org/10.2991/idcsu-17.2018.72How to use a DOI?
- Osteoporosis, bone, resorption, hormone
- Increasing age, especially in postmenopausal women, shows a decline in anabolic hormones activity and an increase in anti-anabolic hormones activity. This causes bone resorption and may lead to osteoporosis. Osteoporosis is a degenerative disorder marked by decrease in bone mass because of imbalance between bone resorption and formation. Bone strength is determined by morphology, bone structure & geometry, bone remodelling and quality of extracellular matrix. The balance in bone resorption and formation determines bone density and affects one's susceptibility to bone fracture. Bone resorption is affected by bone metabolism process on cellular level, and on edentulous areas is more affected by hormonal, nutritional and metabolism factors. Morrison and Coll have found that there are many polymorphisms in osteoporosis etiopathogenesis, some among them showing a large influence on BMD (Bone mineral density) compared to others, including Estrogen, VDR, COLIA1, PTH, PTHR1,and encoding genes for some cytokines and growth factors.
- Open Access
- This is an open access article distributed under the CC BY-NC license.
Cite this article
TY - CONF AU - Susi R. Puspitadewi AU - Elza I. Auerkari PY - 2018/02 DA - 2018/02 TI - Hormonal and Genetic Role Affecting the Bone Resorption in Patients with Osteoporosis PB - Atlantis Press SP - 282 EP - 287 SN - 2468-5739 UR - https://doi.org/10.2991/idcsu-17.2018.72 DO - https://doi.org/10.2991/idcsu-17.2018.72 ID - R.Puspitadewi2018/02 ER -