Hormonal and Genetic Role Affecting the Bone Resorption in Patients with Osteoporosis

DOI

10.2991/idcsu-17.2018.72How to use a DOI?

Keywords

Osteoporosis, bone, resorption, hormone

Abstract

Increasing age, especially in postmenopausal women, shows a decline in anabolic hormones activity and an increase in anti-anabolic hormones activity. This causes bone resorption and may lead to osteoporosis. Osteoporosis is a degenerative disorder marked by decrease in bone mass because of imbalance between bone resorption and formation. Bone strength is determined by morphology, bone structure & geometry, bone remodelling and quality of extracellular matrix. The balance in bone resorption and formation determines bone density and affects one's susceptibility to bone fracture. Bone resorption is affected by bone metabolism process on cellular level, and on edentulous areas is more affected by hormonal, nutritional and metabolism factors. Morrison and Coll have found that there are many polymorphisms in osteoporosis etiopathogenesis, some among them showing a large influence on BMD (Bone mineral density) compared to others, including Estrogen, VDR, COLIA1, PTH, PTHR1,and encoding genes for some cytokines and growth factors.

Copyright

© 2018, the Authors. Published by Atlantis Press.

Open Access

This is an open access article distributed under the CC BY-NC license (http://creativecommons.org/licenses/by-nc/4.0/).

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TY  - CONF
AU  - Susi R. Puspitadewi
AU  - Elza I. Auerkari
PY  - 2018/02
DA  - 2018/02
TI  - Hormonal and Genetic Role Affecting the Bone Resorption in Patients with Osteoporosis
BT  - Proceedings of the International Dental Conference of Sumatera Utara 2017 (IDCSU 2017)
PB  - Atlantis Press
SP  - 282
EP  - 287
SN  - 2468-5739
UR  - https://doi.org/10.2991/idcsu-17.2018.72
DO  - 10.2991/idcsu-17.2018.72
ID  - R.Puspitadewi2018/02
ER  -