Naturally Inhibited Yacon Tubers Prebiotic Syrup Increases Humoral and Cellular Immunity
- 10.2991/aer.k.211215.089How to use a DOI?
- Prebiotic syrup; Humoral; Cellular immunity
The aim of the study: to obtain yacon prebiotic syrup that can increase cellular and humoral immunity. Sixty of Rattus norvegicus aged about 40 days and weighing about 100-150 grams divided into 4 groups. Commercial FOS supplement group, non-inhibited yacon syrup, inhibited yacon syrup (FOS content ± 20% w/w diet), and water as a negative control. Induction of 2% sheep red blood cell antigen via intraperitoneal injection. Bioactive assay of FOS and chlorogenic acid in yacon syrup using HPLC and voltametry. CD4+/CD8+ cellular immunity was tested by floxytometry, while IgM and IgG humoral immunity by antibody titrant hemagglutination method. Data were analyzed statistically parametric and non parametric (α = 5%). The results showed: 1) inhibited yacon syrup had higher content of bioactive FOS and chlorogenic acid than non-inhibited yacon syrup. 2) The use of natural inhibitors is effective in maintaining the bioactive content of yacon tubers. 3) Supplementation of inhibited yacon syrup more effective in increasing cellular (CD4+/CD8+) and humoral (IgM and IgG) immunity against the control group than the non-inhibited yacon syrup.
- © 2021 The Authors. Published by Atlantis Press International B.V.
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Cite this article
TY - CONF AU - Leny Yuanita AU - Prima R. Wikandari AU - Dewi Prastiwi AU - Raymond I. Avandi AU - Wahyu B. Sabtiawan AU - Erlix R. Purnama PY - 2021 DA - 2021/12/16 TI - Naturally Inhibited Yacon Tubers Prebiotic Syrup Increases Humoral and Cellular Immunity BT - Proceedings of the International Joint Conference on Science and Engineering 2021 (IJCSE 2021) PB - Atlantis Press SP - 526 EP - 531 SN - 2352-5401 UR - https://doi.org/10.2991/aer.k.211215.089 DO - 10.2991/aer.k.211215.089 ID - Yuanita2021 ER -